Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection Scientists observed that influenza virus induced robust expression of interferon lambda (IFN-?) in alveolar epithelial cells mainly through a RIG-I-dependent pathway, but IFN-?-induced phosphorylation of the signal transducer and activator of transcription protein 1 was dramatically inhibited in the infected cells. [PLoS Pathog] Full Article Ex Vivo Chemical Cytometric Analysis of Protein Tyrosine Phosphatase Activity in Single Human Airway Epithelial Cells Investigators describe a novel method for the measurement of protein tyrosine phosphatase activity in single human airway epithelial cells using capillary electrophoresis. [Anal Chem] Abstract Inhibition of Airway Epithelial-to-Mesenchymal Transition and Fibrosis by Kaempferol in Endotoxin-Induced Epithelial Cells and Ovalbumin-Sensitized Mice Researchers investigated whether 1-20?µM kaempferol inhibited lipopolysaccharide (LPS)-induced bronchial epithelial-to-mesenchymal transition (EMT) in BEAS-2B cells. LPS induced airway epithelial TGF-ß1 signaling that promoted EMT with concurrent loss of E-cadherin and induction of a-smooth muscle actin. [Lab Invest] Abstract SWCNTs Induced Autophagic Cell Death in Human Bronchial Epithelial Cells Scientists investigated the alterations in cellular response with morphological changes induced by single-walled carbon nanotubes (SWCNTs) in BEAS-2B cells, a human bronchial epithelial cell line. [Toxicol In Vitro] Abstract S-Nitrosothiols Increases Cystic Fibrosis Transmembrane Regulator Expression and Maturation in the Cell Surface Human bronchial airway epithelial cells expressing F508del cystic fibrosis transmembrane conductance regulator (CFTR) were exposed to S-nitrosoglutathione diethyl ester (GNODE) and S-nitroso-N-acetyl cysteine (SNOAC). The effects of these S-nitrosothiols on the expression and maturation of F508del CFTR were determined by cell surface biotinylation and Western blot analysis. Scientists also found for the first time that GNODE and SNOAC were effective at increasing CFTR maturation at the cell surface. [Biochem Biophys Res Commun] Abstract LUNG CANCER A Reevaluation of CD22 Expression in Human Lung Cancer Recent reports indicate that most human lung cancer cells and cell lines express CD22, making it an important new therapeutic target for lung cancer. The objective of the studies was to independently validate these results with the goal of testing the efficacy of CD22 immunotoxins on lung cancer cell lines. [Cancer Res] Abstract Dickkopf-1 Is Oncogenic and Involved in Invasive Growth in Non Small Cell Lung Cancer RT-PCR and Western blot were used to examine the expression of Dickkopf-1 (DKK1) in a panel of ten human non small cell lung cancer (NSCLC) cell lines and NSCLC tissues. DKK1 expression was highly transactivated in the great majority of these cancer lines. [PLoS One] Full Article B-9-3, A Novel ß-Carboline Derivative Exhibits Anti-Cancer Activity via Induction of Apoptosis and Inhibition of Cell Migration In Vitro In the present study, B-9-3 – a semi-synthetic compound that is formed of two harmane molecules bound by a butyl group – showed a strong anti-cancer activity against a human lung cancer cell line, a human breast cancer cell line, and a human colorectal carcinoma cell line. [Eur J Pharmacol] Abstract Promoter Methylation-Mediated Downregulation of PRDM5 Contributes to the Development of Lung Squamous Cell Carcinoma 5-aza-2′-deoxycitydine inhibited the proliferation of SK-MES-1 cells and the growth of xenografts in nude mice, accompanied by reduced methylation of PRDM5 promoter and increased expression of PRDM5. [Tumor Biol] Abstract MiR-27b Targets LIMK1 to Inhibit Growth and Invasion of NSCLC Cells Researchers found that microRNA (miR)-27b was remarkably decreased in both non-small cell lung cancer (NSCLC) tissues and cell lines. Moreover, overexpression of miR-27b significantly suppressed NSCLC cells proliferation and invasion. [Mol Cell Biochem] Abstract |