Tracking Translocation of Industrially Relevant Engineered Nanomaterials (ENMs) across Alveolar Epithelial Monolayers In Vitro To allow precise quantitation of translocation across lung epithelial cells, researchers developed a method for tracking industrially relevant metal oxide ENMs in vitro using neutron activation. [Nanotoxicology] Abstract IL-33 Stimulates CXCL8/IL-8 Secretion in Goblet Cells but not Normally Differentiated Airway Cells Scientists examined the effect of IL-33 on CXCL8/IL-8 secretion from goblet or normally differentiated human bronchial epithelial cells and signaling pathways associated with IL-33 activation in these cells. [Clin Exp Allergy] Abstract The Role of Pneumococcal Histidine Triad (Pht) Proteins in the Attachment of Streptococcus pneumoniae to Respiratory Epithelial Cells Scientists assessed the role of Pht proteins in pneumococcal binding to respiratory epithelial cells. Pneumococci were incubated with human nasopharyngeal epithelial cells and lung epithelial cells and the proportion of bound bacteria was measured by plating viable counts. [Infect Immun] Abstract Microfluidic Shear Stress-Regulated Surfactant Secretion in Alveolar Epithelial Type II Cells In Vitro Researchers investigated the role of flow-induced shear stress on the mechanisms regulating surfactant secretion in type II alveolar epithelial cells using microfluidic models. [Am J Physiol Lung Cell Mol Physiol] Abstract Cadmium Induces Cytotoxicity in Human Bronchial Epithelial Cells through Upregulation of eIF5A1 and NF-KappaB Researchers report that in CdCl2-exposed human bronchial epithelial cells, the level of p53 is dramatically decreased in a time- and dose-dependent manner, suggesting that the observed cadmium-induced cytotoxicity is not likely due to the pro-apoptotic function of p53. [Biochem Biophys Res Commun] Abstract Protective Effect of Luteolin on Cigarette Smoke Extract-Induced Cellular Toxicity and Apoptosis in Normal Human Bronchial Epithelial Cells via the Nrf2 Pathway Researchers evaluated the protective effects of luteolin on cigarette smoke extract-induced toxicity and apoptosis in normal human bronchial epithelial cells and explored its underlying mechanism(s). [Oncol Rep] Abstract LUNG CANCER Antitumor Effect of miR-197 Targeting in p53 Wild-Type Lung Cancer Scientists employed a locked nucleic acid-based anti-microRNA (miR) library in a functional screening to identify putative oncogenic miRNAs in non-small-cell lung cancer. By screening NIH-H460 and A549 cells, miR-197 was identified as a new functional oncomiR, whose downregulation induces p53-dependent lung cancer cell apoptosis and impairs the capacity to establish tumor xenografts in immunodeficient mice. [Cell Death Differ] Abstract A Novel Cyclometallated Pt(II)-Ferrocene Complex Induces Nuclear FOXO3a Localization and Apoptosis and Synergizes with Cisplatin to Inhibit Lung Cancer Cell Proliferation Researchers report the antiproliferative activity of a novel diastereomerically pure cycloplatinated complex 6a, against A549 non-small cell lung cancer. Mechanistic studies revealed that compound 6a induces nuclear translocation of a FOXO3a reporter protein as well as endogenous FOXO3a in U2OS and A549 cells, respectively. [Metallomics] Abstract Aflatoxin G1-Induced Oxidative Stress Causes DNA Damage and Triggers Apoptosis through MAPK Signaling Pathway in A549 Cells Researchers explored whether Aflatoxin G1 activates the reactive oxygen species/MAPK/apoptosis pathway to cause cell damage in human alveolar type II cells like the cell line A549. [Food Chem Toxicol] Abstract Crizotinib Inhibits Migration and Expression of ID1 in MET-Positive Lung Cancer Cells: Implications for MET Targeting in Oncology Crizotinib decreased p-MET, p-SRC and ID1 levels in ALK- and or MET-positive cell lines and inhibited cell migration. Knockdown of MET was comparable with the effect of crizotinib. [Future Oncol] Abstract Win a $25 Amazon Gift Card! Connexon Creative is evaluating reader interest in a new social media platform. Fill out this quick survey for your chance to win 1 of 4 $25 gift cards! Take survey here |