Pulmonary Cell News Volume 3.10 | Mar 20 2014

Long Noncoding RNA Are Aberrantly Expressed In Vivo in the Cystic Fibrosis Bronchial Epithelium
Scientists examined the expression profile of long non-coding RNAs (lncRNAs), in the airway epithelium of people with cystic fibrosis (CF). They examined the expression of 30,586 lncRNAs by microarray, in vivo in bronchial cells isolated from endobronchial brushings obtained from CF and non-CF individuals. [Int J Biochem Cell Biol] Abstract

Short-Term Cigarette Smoke Exposure Leads to Metabolic Alterations in Lung Alveolar Cells
Scientists examined the effect of cigarette smoke exposure on metabolism in alveolar type II cells. Palmitate utilization was accompanied by an increase in the expression of CD36 and carnitine-palmitoyl transferase 1 in type II alveolar cells, for the transport of palmitate into the cells and into mitochondria, respectively. [Am J Respir Cell Mol Biol] Abstract

Identification of an Outer Membrane Lipoprotein Involved in Nasopharyngeal Colonization by Moraxella catarrhalis in an Animal Model
Colonization of the human nasopharynx by Moraxella catarrhalis is presumed to involve attachment of this bacterium to the mucosa. DNA microarray analysis was used to determine whether attachment of M. catarrhalis to human bronchial epithelial cells in vitro affected gene expression in this bacterium. [Infect Immun] Abstract

LUNG CANCER

PCK2 Activation Mediates an Adaptive Response to Glucose Depletion in Lung Cancer
Researchers showed that the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PCK2) is expressed and active in three lung cancer cell lines and in non-small cell lung cancer samples. [Oncogene] Abstract

GSK3ß Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells
Researchers investigated the influence of glycogen synthase kinase 3 beta (GSK3ß) expression on the prognosis of human non-small cell lung cancer (NSCLC) and the effects of GSK3ß inhibition in NSCLC cell lines. [PLoS One] Full Article

Cantharidin Induces DNA Damage and Inhibits DNA Repair-Associated Protein Levels in NCI-H460 Human Lung Cancer Cells
Researchers determined whether cantharidin induced DNA damage and condensation and altered levels of proteins in NCI-H460 cells in vitro. [Environ Toxicol] Abstract

Autocrine Signaling via Release of ATP and Activation of P2X7 Receptor Influences Motile Activity of Human Lung Cancer Cells
Investigators showed that autocrine signaling through release of ATP and activation of P2X7 receptor influences migration of human lung cancer cells. [Purinergic Signal] Abstract

The Tumor-Suppressing Activity of the Prenyl Diphosphate Synthase Subunit 2 Gene in Lung Cancer Cells
Scientists investigated the tumor-suppressing activity of prenyl diphosphate synthase subunit 2 (PDSS2) in lung cancer cells using cellular and molecular tools. The PDSS2 gene has low levels of expression in human lung cancer cell lines. [Anticancer Drugs] Abstract

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VaxInnate Begins Phase I Clinical Trial to Evaluate Quadrivalent Vaccine for Prevention of Seasonal Flu
VaxInnate Corporation announced that enrollment has commenced in a Phase I clinical trial to evaluate VAX2012Q, a recombinant quadrivalent vaccine in development for the prevention of seasonal influenza. [VaxInnate Corporation] Press Release

Ohio State Partners with MedVax Technologies, Inc. to Bring a Cancer Peptide Vaccine to Patients
The Ohio State University, through the Ohio State Innovation Foundation, has signed an exclusive world-wide licensing agreement with MedVax Technologies, Inc., for the licensing of groundbreaking cancer peptide vaccine technologies. The anticancer vaccine technologies are designed for the treatment and prevention of cancers associated with the HER2 protein. [The Ohio State University] Press Release

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Postdoctoral Scholar – Mechanisms of Pathologic Mucus Gel Formation in Diseases of the Lung (University of California, San Francisco)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Pulmonary Research (Cedars-Sinai Medical Center)

Junior Research Group Leader – Stem Cell Based Therapies for Lung Diseases (Hannover Medical School)

Postdoctoral Scientist – Small Cell Lung Cancer Circulating Tumor Cell Derived Explant Tumor Models (Cancer Research UK Manchester Institute)

Postdoctoral Position – Novel Therapeutic Approaches to the Treatment of Lung Cancer (Sloan Kettering Institute)

PhD Studentships in Pulmonary Medicine (University of Giessen and Marburg Lung Center)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (UCSF)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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