Gene Expression Profile and Toxic Effects in Human Bronchial Epithelial Cells Exposed to Zearalenone Scientists identified the responses and underlying molecular changes that occur when human bronchial epithelial BEAS-2B cells are exposed to zearalenone. [PLoS One] Full Article The Use of a Three-Dimensional Cell Culture Model to Investigate Host-Pathogen Interactions of Francisella tularensis in Human Lung Epithelial Cells Scientists investigated a three-dimensional cell-culture system to characterize the epithelial response to F. tularensis. Immortalized human pneumocytes grown in rotating-wall vessel bioreactors display an in vivo-like phenotype, which has been confirmed to be driven by specific transcriptional events. [Microbes Infect] Abstract Cigarette Smoke Alters Non-Neuronal Cholinergic System Components Inducing MUC5AC Production in the H292 Cell Line Mucin 5AC (MUC5AC), muscarinic acetylcholine receptor M3, choline acetyl-transferase, acetylcholine expression and acetylcholine binding significantly increased in H292 cells stimulated with cigarette smoke extract compared to untreated cells. [Eur J Pharmacol] Abstract Effect of Thymic Stromal Lymphopoietin on MUC5B Expression in Human Airway Epithelial Cells The effects and brief signaling pathways of thymic stromal lymphopoietin on expression of mucin genes in human airway epithelial cells were investigated in this study. [Biochem Biophys Res Commun] Abstract LUNG CANCER Prognostic and Therapeutic Implications of Aromatase Expression in Lung Adenocarcinomas with EGFR Mutations Inhibitory effects of the aromatase inhibitor exemestane were assessed in lung adenocarcinoma cell lines that have EGFR mutations, separately and combined with EGFR tyrosine kinase inhibitor erlotinib. [Clin Cancer Res] Abstract Co-Delivery of Doxorubicin and Paclitaxel by PEG-Polypeptide Nanovehicle for the Treatment of Non-Small Cell Lung Cancer In vitro cytotoxicity assays against A549 human lung adenocarcinoma cell line demonstrated that the doxorubicin + paclitaxel co-delivered nanoparticles exhibited synergistic effect in inducing cancer cell apoptosis. [Biomaterials] Abstract Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo Researchers investigated the antitumor activity of silybin towards human lung adenocarcinoma cells in vitro and in vivo and explored the role of the silent information regulator 1 (SIRT1) signaling pathway in this process. [Mol Cancer Ther] Abstract Grape Seed Proanthocyanidins Inhibit Cigarette Smoke Condensate-Induced Lung Cancer Cell Migration through Inhibition of NADPH Oxidase and Reduction in the Binding of p22phox and p47phox Proteins Researchers report that grape seed proanthocyanidins exert an inhibitory effect on the cigarette smoke condensate-induced migration of non-small cell lung cancer cells. [Mol Carcinog] Abstract Aquaporin 3 Knockdown Suppresses Tumor Growth and Angiogenesis in Experimental Non-Small Cell Lung Cancer Scientists tested the anti-tumor effects of short hairpin RNA targeting aquaporin 3 (AQP3) in experimental non-small-cell lung cancer (NSCLC). AQP3 expression was suppressed in human A549 and H1299 NSCLC cell lines by short hairpin RNA-mediated silencing. [Exp Physiol] Abstract |