Alterations of Bronchial Epithelial Metabolome by Cigarette Smoke Are Reversible by an Antioxidant UPF1 Researchers aimed to determine the dynamics of metabolome changes in human bronchial epithelial cells treated with cigarette smoke condensate and to test whether normal metabolism can be restored by synthetic antioxidants. [Am J Respir Cell Mol Biol] Abstract Pim1 Kinase Protects Airway Epithelial Cells from Cigarette Smoke Induced Damage and Airway Inflammation Human bronchial epithelial BEAS-2B cells were treated with cigarette smoke extract in presence or absence of Pim1 inhibitor, and assessed for loss of mitochondrial membrane potential, induction of cell death and release of HSP70. [Am J Physiol Lung Cell Mol Physiol] Abstract Gene Expression Profiles Reveal Distinct Immunological Responses of Cobalt and Cerium Dioxide Nanoparticles in Two In Vitro Lung Epithelial Cell Models Scientists performed a time kinetic study of gene expression profiles induced by these nanoparticles in alveolar A549 and bronchial BEAS-2B epithelial cells, and investigated possible immune system modulation. [Toxicol Lett] Abstract Comparative Effects between Electronic and Cigarette Smoke in Human Keratinocytes and Epithelial Lung Cells Skin and lung cells, the main targets of cigarette smoke (CS), were exposed to electronic cigarettes vapor and CS using an in vitro system. The cytotoxic effect of the exposure was analyzed in both cell types by ultrastructural morphology, Trypan Blue exclusion test and LDH assay. [Toxicol In Vitro] Abstract LUNG CANCER Exposure to 9,10-Phenanthrenequinone Accelerates Malignant Progression of Lung Cancer Cells through Up-Regulation of Aldo-Keto Reductase 1B10 Researchers showed that treatment with high concentrations of 9,10-phenanthrenequinone evokes apoptosis of lung cancer A549 cells through production of reactive oxygen species. [Toxicol Appl Pharmacol] Abstract Huaier Suppresses Proliferation and Induces Apoptosis in Human Pulmonary Cancer Cells via Upregulation of miR-26b-5p Transfection of A549 cells with miR-26b-5p mimic inhibited proliferation and induced apoptosis, while transfection of Huaier-treated A549 cells with a miR-26b-5p inhibitor reversed the effects of Huaier. [FEBS Lett] Full Article Cantharidin Induces Apoptosis of H460 Human Lung Cancer Cells through Mitochondria-Dependent Pathways Researchers investigated the effect of cantharidin on the cell death via the induction of apoptosis in H460 human lung cancer cells. [Int J Oncol] Abstract SchA-p85-FAK Complex Dictates Isoform-Specific Activation of Akt2 and Subsequent PCBP1-Mediated Post-Transcriptional Regulation of TGFβ-Mediated Epithelial to Mesenchymal Transition in Human Lung Cancer Cell Line A549 TGF-β induced epithelial to mesenchymal transition (EMT) in A549 cells concomitant with translational upregulation of disabled-2 and interleukin-like EMT inducer proteins through isoform-specific activation of Akt2 followed by phosphorylation of poly r(C) binding protein (PCBP1) at serine-43. [Tumor Biol] Abstract |