Pulmonary Cell News Volume 3.24 | Jun 26 2014

Chronic Alcohol Ingestion in Rats Alters Lung Metabolism, Promotes Lipid Accumulation, and Impairs Alveolar Macrophage Functions
Scientists studied the metabolic consequences of chronic alcohol consumption in rat lungs in vivo and in alveolar epithelial type II cells and alveolar macrophages in vitro. [Am J Respir Cell Mol Biol] Abstract

Cell Stress Induces Upregulation of Osteopontin via the ERK Pathway in Type II Alveolar Epithelial Cells
Investigators demonstrate the molecular mechanism of osteopontin (OPN) induction in type II alveolar epithelial cells (AEC II) and elucidate the functions of OPN in AEC II and lung fibroblasts. [PLoS One] Full Article

Accumulation of Metals in GOLD4 COPD Lungs is Associated with Decreased CFTR Levels
The effect of cigarette smoke on down-regulation of cystic fibrosis transmembrane conductance regulator (CRTR) expression and function was assessed by researchers using primary human airway epithelial cells. [Respir Res] Abstract | Full Article

LUNG CANCER

IL-1β-Mediated Repression of MicroRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis
Scientists report that the pro-inflammatory cytokine IL-1β is dramatically elevated in the serum of patients with non-small cell lung cancer. [Cancer Res] Abstract

IL-6 Enriched Lung Cancer Stem-Like Cell Population by Inhibition of Cell Cycle Regulators via DNMT1 Up-Regulation
Researchers demonstrate that IL-6 enriches the properties of lung cancer stem-like cells in A549 lung cancer cells cultured in spheroid medium. IL-6 also promotes sphere formation and stem-like properties of A549 cells by enhancing cell proliferation. [Int J Cancer] Abstract

KPT-330 Has Antitumor Activity against Non-Small Cell Lung Cancer
Scientists investigated the biologic and pharmacologic activities of a chromosome region maintenance 1 inhibitor against human non-small cell lung cancer cells both in vitro and in vivo. [Brit J Cancer] Abstract

Cooperation of Tyrosine Kinase Receptor and Epidermal Growth Factor Receptor Signaling Enhances Migration and Dispersal of Lung Tumor Cells
Based on recent reports that tyrosine kinase receptor (TrkB) can also be transactivated through epidermal growth-factor receptor signaling and thus regulates migration of early neurons, scientists investigated the role of TrkB in migration of lung tumor cells. [PLoS One] Full Article

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New Immuno-Oncology Lung Cancer Collaboration Launched with Dana-Farber’s Belfer Institute; One of Seven New Strategic Oncology Partnerships
Johnson & Johnson Innovation announced a three-year collaboration with the Dana-Faber Cancer Institute’s Belfer Institute for Applied Cancer Science to determine which lung cancer patients are most likely to benefit from a new generation of immuno-oncology therapies. [Johnson & Johnson Innovation LLC] Press Release

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NEW Postdoctoral Research Trainee – Lung Injury and Epithelial Repair (University of Tennessee Health Science Center)

NEW Director, US Medical Affairs – Lung Job (Celgene Corporation)

Postdoctoral Scholar – Molecular Mechanisms of Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Primary Cell Culture Position – Heart/Lung Disease (Paramount Recruitment)

Postdoctoral Fellow – Lung Cancer Biomarker Discovery and Applications (Shantou University)

Postdoctoral Position – Molecular and Cell Biology (Cornell University)

Junior Research Group Leader Position – Cell-Derived Therapeutics in Chronic Lung Disease (Helmholtz Zentrum München)

Postdoctoral Fellow – Lung Biology and Genomics (Harvard University)

Postdoctoral Fellowship – Malignant Progression of Lung Cancer (MD Anderson Cancer Center)

Research Fellow – Pulmonary Cancer (Mayo Clinic – Rochester)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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