Pulmonary Cell News Volume 4.01 | Jan 15 2015

Airway Epithelial Cell Integrity Protects from Cytotoxicity of P. aeruginosa Quorum-Sensing Signals
Pseudomonas aeruginosa N-3-oxo-dodecanoyl-L-homoserine lactone (C12) degradation and its effects on cells were monitored in various airway epithelial cell models grown under non-polarized and polarized conditions. C12 rapidly altered epithelial integrity and decreased gap junctional intercellular communication in non-polarized airway epithelial cells while other quorum-sensing molecules had no effect. [Am J Respir Cell Mol Biol] Abstract

Toxicity of Copper Oxide Nanoparticles in Lung Epithelial Cells Exposed at the Air-Liquid Interface Compared with In Vivo Assessment
The toxicity of spark-generated copper oxide nanoparticles was evaluated in human bronchial epithelial cells and lung adenocarcinoma cells using an in vitro air-liquid interface exposure system. [Toxicol In Vitro] Abstract

Integrin-Linked Kinase Mediates CTGF-Induced Epithelial to Mesenchymal Transition in Alveolar Type II Epithelial Cells
Alveolar type II epithelial cells were isolated from four weeks old connective tissue growth factor (CTGF)-overexpressing mice and control littermates, and cultured on Matrigel. Cells were transfected with integrin-linked kinase siRNA, and cell morphology and expression of cell differentiation markers were analyzed. [Pediatr Res] Abstract

LUNG CANCER

Curcumin Inhibits Proliferation-Migration of NSCLC by Steering Crosstalk between a Wnt Signaling Pathway and an Adherens Junction via EGR-1
A microarray analysis of differential genes by curcumin treatment was performed and the crucial pathways associated with non-small cell lung cancer were investigated. Function enrichment analysis indicated the differentially expressed genes were mainly involved in the steroid biosynthetic process and regulation of autophagy. [Mol Biosyst] Abstract

Down-Regulation of TIMP-1 Inhibits Cell Migration, Invasion, and Metastatic Colonization in Lung Adenocarcinoma
Researchers demonstrate that the expression level of tissue inhibitor metalloproteinase-1 (TIMP-1) positively associates with cell mobility, invasiveness, and metastatic colonization. Most notably, the novel mechanism in which TIMP-1 facilitates metastatic colonization through the mediation of pericellular polyFN1 assembly was revealed. [Tumor Biol] Abstract

Luteolin Acts as a Radiosensitizer in Non-Small Cell Lung Cancer Cells by Enhancing Apoptotic Cell Death through Activation of a p38/ROS/Caspase Cascade
Treatment with luteolin or γ-ionizing radiation (IR) induced non-small cell lung cancer cell death in vitro, but the combination of luteolin pre-treatment and IR was more effective than either agent alone. [Int J Oncol] Abstract

The Combination of Hsp90 Inhibitor 17AAG and Heavy-Ion Irradiation Provides Effective Tumor Control in Human Lung Cancer Cells
SQ5 human lung tumor cells were used in vitro for clonogenic cell survival and in vivo for tumor growth delay measurement using a mouse xenograft model after 17-allylamino-17-demethoxygeldanamycin pretreatment and carbon ion irradiation. [Cancer Med] Abstract

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CheckMate -017, A Phase III Study of Opdivo (Nivolumab) Compared to Docetaxel in Patients with Second-Line Squamous Cell Non-small Cell Lung Cancer, Stopped Early
Bristol-Myers Squibb Company announced that an open-label, randomized Phase III study evaluating Opdivo versus docetaxel in previously treated patients with advanced, squamous cell non-small cell lung cancer was stopped early because an assessment conducted by the independent Data Monitoring Committee concluded that the study met its endpoint, demonstrating superior overall survival in patients receiving Opdivo compared to the control arm. [Bristol-Myers Squibb Company] Press Release

Aradigm Granted Key Composition of Matter Patents for Pulmaquin in Europe and Australia
Aradigm Corporation announced that the European Patent Office has issued an important new composition of matter patent entitled “Dual Action, Inhaled Formulations Providing Both an Immediate and Sustained Release Profile,” to Aradigm for formulations of liposomal and free ciprofloxacin. [Aradigm Corporation] Press Release

PharmaMar Will Start a Phase III Study of PM1183 in Combination with Doxorubicin in Relapsed SCLC
Zeltia announced that its pharmaceutical division PharmaMar will start a Phase III trial with PM1183 in combination with doxorubicin against topotecan in SCLC, given the activity observed in an interim analysis of an ongoing Phase Ib trial. [Zeltia] Press Release

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NEW Postdoctoral Fellow – Cystic Fibrosis Research (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Staff Scientist – Lung Cancer (University of Pennsylvania)

Postdoctoral Fellow – Cytokine-Induced Lung Inflammation (Cleveland Clinic Lerner Research Institute)

Postdoctoral Positions – Lung and Dermal Uptake Modeling (Karolinska Institutet)

Postdoctoral Position – Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

Postdoctoral Positions – Lung Development and Progenitor Cell Biology (Columbia University)

Postdoctoral Researcher – Chromatin and Epigenetic Regulation (Van Andel Research Institute)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Research Technologist – Media Development (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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