ABCA3 Protects Alveolar Epithelial Cells against Free Cholesterol Induced Cell Death Scientists found that wild type ABCA3 reduces cellular free cholesterol levels, induces the SREBP pathway, and renders cells more resistant to loading with exogenous cholesterol. Moreover, ABCA3 mutations found in patients with diffuse parenchymal lung disease interfere with this protective effect of ABCA3, resulting in free cholesterol induced cell death. [Biochim Biophys Acta] Abstract A Multi-Omics Approach Identifies Key Hubs Associated with Cell Type-Specific Responses of Airway Epithelial Cells to Staphylococcal Alpha-Toxin Researchers compared two human bronchial epithelial cell lines, i.e. Hla-susceptible 16HBE14o- and Hla-resistant S9 cells, by a quantitative multi-omics strategy for a better understanding of Hla-induced cellular programs. [PLoS One] Full Article Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells Scientists showed that cigarette smoke condensate has the ability to activate the human papillomavirus type 16 p97 promoter by acting on the long control region in lung epithelial cells. [PLoS One] Full Article Identification of Helicobacter pylori VacA in Human Lung and Its Effects on Lung Cells Researchers tested the hypothesis that VacA, an exotoxin of H. pylori, a gastric pathogen, was aspirated into the lung and could stimulate secretion of inflammatory cytokines by lung epithelial cells. [Biochem Biophys Res Commun] Abstract LUNG CANCER Suberoylanilide Hydroxamic Acid Treatment Reveals Crosstalks among Proteome, Ubiquitylome and Acetylome in Non-Small Cell Lung Cancer A549 Cell Line By using SILAC technique, antibody-based affinity enrichment and high-resolution LC-MS/MS analysis, scientists investigated quantitative proteome, acetylome and ubiquitylome as well as crosstalks among the three datasets in A549 cells toward suberoylanilide hydroxamic acid treatment. [Sci Rep] Full Article Functional Role and Mechanism of lncRNA LOC728228 in Malignant 16HBE Cells Transformed by Anti-Benzopyrene-trans-7,8-Dihydrodiol-9,10-Epoxide Scientists attempted to identify lung-cancer-related long noncoding RNAs (lncRNAs). They found changes in lncRNA expression in the anti-benzo(a) pyrene-7,8-diol-9,10-epoxide-transformed human bronchial epithelial cell line using microarrays and qRT-PCR. [Mol Carcinog] Abstract Endothelial PAS Domain-Containing Protein 1 Confers TKI-Resistance by Mediating EGFR and MET Pathways in Non-Small Cell Lung Cancer Cells Researchers report that endothelial PAS domain-containing protein 1, with 48% sequence identity to hypoxia-inducible factor-1α, specifically binds to TKI-resistant T790M epidermal growth factor receptor (EGFR), but not to wild-type EGFR, in non-small-cell lung cancer cell lines. [Cancer Biol Ther] Abstract Improvement of Anti-Tumor Abilities on Human Non-Small Cell Lung Carcinoma by Micellization and Cross-Linking of N-(2-Hydroxypropyl) Methacrylamide Copolymers The characteristics of N-(2-hydroxypropyl) methacrylamide micelles were investigated and compared using human non-small cell lung carcinoma 3-D culture model and nude mice xenograft model. Cross-linked micelles showed highest cytotoxicity on A549 cell monolayers after a short time treatment in vitro. [J Drug Target] Abstract Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells Is Associated with Radioresistance of Lung Cancer Scientists demonstrated that miR-21 and miR-95 expression were significantly higher in the ALDH1+CD133+subpopulation than in the ALDH1–CD133– subpopulation of lung cancer cells. [Cancer Invest] Abstract |