Pulmonary Cell News Volume 4.17 | May 7 2015

Is the Cellular Uptake of Respiratory Aerosols Delivered from Different Devices Equivalent?
Deposition and transport profiles of three different inhaled salbutamol sulphate formulations with clinically relevant doses were evaluated using a modified Andersen Cascade Impactor coupled with the air interface Calu-3 bronchial cell model. [Eur J Pharm Biopharm] Abstract

Motile Cilia Harbor Serum Response Factor as a Mechanism of Environment Sensing and Injury Response in the Airway
Using a mouse model of organic dust-induced airway inflammation, researchers found that the transcription factor serum response factor localizes to motile cilia of airway epithelial cells and alters its localization in response to inflammatory stimuli. [Am J Physiol Lung Cell Mol Physiol] Full Article

Plasminogen Activator Inhibitor-1 in Cigarette Smoke Exposure and Influenza A Virus Infection-Induced Lung Injury
Investigators found increased p53, PAI-1 and apoptosis in alveolar epithelial cells, with accumulation of macrophages and neutrophils in the lungs of patients with chronic obstructive pulmonary disease. [PLoS One] Full Article

LUNG CANCER

Activated Cdc42-Associated Kinase Is Up-Regulated in Non-Small-Cell Lung Cancer and Necessary for FGFR-Mediated AKT Activation
Scientists found that the expression of activated cdc42-associated tyrosine kinase 1 (ACK1) was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples compared to their adjacent normal tissues. ACK1 was further validated to promote the growth, migration, and metastasis of NSCLC cells in vitro and in vivo. [Mol Carcinog] Abstract

Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells
Researchers examined the roles of autophagy in the death of multidrug resistant (MDR) A549 lung cancer sublines by a fungal protein from G. microsporum, thapsigargin (TG) and tunicamycin (TM) in vitro. Cytotoxicity of TG was inhibited by overexpressed p-glycoprotein (P-gp). However, TM-induced death of MDR sublines was independent of P-gp level. [PLoS One] Full Article

Nonsense and Missense Mutation of Mitochondrial ND6 Gene Promotes Cell Migration and Invasion in Human Lung Adenocarcinoma
The authors investigated the possible role of mitochondrial ND6 (mitND6) gene nonsense and missense mutations in the metastasis of human lung adenocarcinoma. They studied the effects of mitND6 gene nonsense and missense mutations on cell migration and invasion through wounding healing and matrigel-coated transwell assay. [BMC Cancer] Abstract | Full Article

NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells
Investigators demonstrated the effects of semisynthesized NBM-T-BBX-OS01 from osthole on histone deacetylase (HDAC)6-mediated growth arrest in lung cancer cells. [Molecules] Abstract | Download Full Article

Alveolar Development and Disease
Identification of surfactant proteins, cloning of the genes encoding them, and elucidation of their roles in the regulation of surfactant synthesis, structure, and function has provided increasing understanding of alveolar function and homeostasis in health and disease. This “perspective” seeks to consider developmental aspects of the pulmonary surfactant system and its importance in the pathogenesis of acute and chronic lung diseases related to alveolar homeostasis. [Am J Respir Cell Mol Biol] Abstract

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FDA Approves BREO^® ELLIPTA^® for the Treatment of Adults with Asthma in the US
GlaxoSmithKline plc and Theravance, Inc. announced that the US Food and Drug Administration (FDA) has approved BREO^® ELLIPTA^® for the once-daily treatment of asthma in patients aged 18 years and older. [GlaxoSmithKline plc] Press Release

EMD Serono Initiates Co-Promotion of XALKORI^® (Crizotinib) with Pfizer in the United States
EMD Serono announced it has begun co-promoting Pfizer’s anaplastic lymphoma kinase inhibitor XALKORI^® (crizotinib) as part of its global strategic alliance with Pfizer. [EMD Serono] Press Release

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NEW Postdoctoral Position – Immunology and Virology (Herman B Wells Center for Pediatric Research)

NEW Postdoctoral Researcher – Systems Biology (Van Andel Research Institute)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Research Specialist – Lung and Vascular Biology (University of Illinois Chicago College of Medicine)

Postdoctoral Research Position – Lung Cancer (University of California, San Francicso)

Professorship – Lung Epithelial Cell Plasticity (Ludwig-Maximilians-Universitat München)

PhD Position – Development of a 3D In Vitro Model of Infected Airway (Helmholtz Centre for Infection Research)

Postdoctoral Researcher – Pulmonary Developmental Pathology (Drexel University College of Medicine)

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