Pulmonary Cell News Volume 4.33 | Aug 27 2015

Lipoxin A₄ Activates Alveolar Epithelial Sodium Channel Gamma via the MicroRNA-21/PTEN/AKT Pathway in Lipopolysaccharide-Induced Inflammatory Lung Injury
Researchers investigated the mechanisms of lipoxin A4 (LXA₄) in modulation of epithelial sodium channel gamma in lipopolysaccharide (LPS)-induced inflammatory lung injury. miR-21 was upregulated during an LPS challenge and downregulated by LXA₄ administration in vivo and in vitro. [Lab Invest] Abstract

Oxidative Stress and Endocytosis Are Involved in Upregulation of Interleukin-8 Expression in Airway Cells Exposed to PM2.5
The mechanisms underlying PM2.5-induced IL-8 gene expression have not been fully characterized. BEAS-2B cells and THP-1 cells were used as the in vitro models to investigate the underlying mechanism in this study. [Environ Toxicol] Abstract

Nuclear Translocation of Nuclear Factor Kappa B Is Regulated by G Protein Signaling Pathway in Arsenite-Induced Apoptosis in HBE Cell Line
Using human bronchial epithelial cells as a culture system, scientists demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis. [Environ Toxicol] Abstract

Expression and DNA Methylation Status of the Rap2B Gene in Human Bronchial Epithelial Cells Treated by Cigarette Smoke Condensate
The authors investigated the Rap2B gene expression and its promoter methylation in human bronchial epithelial cells treated by cigarette smoke condensate. [Inhal Toxicol] Abstract

LUNG CANCER

LRRC3B Is Downregulated in Non-Small-Cell Lung Cancer and Inhibits Cancer Cell Proliferation and Invasion
Researchers checked LRRC3B levels in several lung cancer cell lines and found that its expression was downregulated in four of nine lung cancer cell lines compared with normal human bronchial epithelial cell line. They further explored the biological role of LRRC3B. [Tumour Biol] Abstract

Epigenetic Downregulated ITGBL1 Promotes Non-Small Cell Lung Cancer Cell Invasion through Wnt/PCP Signaling
Researchers found that knockdown of integrin, beta-like 1 (ITGBL1) in non-small cell lung cancer cell lines could promote cancer cell migration and invasion. Furthermore, recombinant ITGBL1 protein-treated cancer cell could inhibit cell migration and invasion. [Tumour Biol] Abstract

Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
Model non-small cell lung cancer cell lines H1975 and H2170 were used to study the similarities and differences in mechanisms of EGFR/c-Met tyrosine kinase inhibitor (TKI) resistance. H1975 cells were positive for the T790M EGFR mutation, which confers resistance to current EGFR TKI therapies, while H2170 cells were EGFR wild-type. [PLoS One] Full Article

KDM6B Elicits Cell Apoptosis by Promoting Nuclear Translocation of FOXO1 in Non-Small Cell Lung Cancer
The authors found that overexpression of KDM6B, a demethylase that acts on histone H3 at lysine 27, inhibited cell growth by initiating mitochondria-dependent apoptosis and by attenuating the invasion-metastasis cascade in non-small cell lung carcinoma cells. [Cell Physiol Biochem] Abstract | Full Article

Association between Downexpression of MiR-203 and Poor Prognosis in Non-Small Cell Lung Cancer Patients
Investigators identified the relationship between miR-203 expression and clinicopathological significance in non-small cell lung cancer patients in the current study. [Clin Transl Oncol] Abstract

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Oncolytics Biotech^® Inc. Collaborators to Present Survival Data from REO 016 Study in Non-Small Cell Lung Cancer
Oncolytics Biotech^® Inc. announced that Dr. Miguel A. Villalona-Calero will make an oral presentation. The presentation, titled “Oncolytic Reovirus in Combination with Paclitaxel/Carboplatin in NSCLC Patients with Ras Activated Malignancies, Long Term Results,” covers updated results, including longer-term survival data, from the company’s REO 016 Phase II study in non-small cell lung cancer (NSCLC). [Press Release from Oncolytics Biotech^® Inc. discussing research to be presented at the International Association for the Study of Lung Cancer (IASLC) 16^th World Conference on Lung Cancer, Denver] Press Release

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FDA and EMA Accept Regulatory Applications for Boehringer Ingelheim’s Giotrif^®/Gilotrif^® (Afatinib) for Treatment of Advanced Squamous Cell Carcinoma of the Lung
Boehringer Ingelheim announced that both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have accepted filing applications for afatinib for the treatment of patients with advanced squamous cell carcinoma of the lung progressing after treatment with first-line chemotherapy. [Boehringer Ingelheim GmbH] Press Release

Oncolytics Biotech® Inc. Announces Completion of Enrollment in Randomized Phase II Non-Small Cell Lung Cancer Study
Oncolytics Biotech^® Inc. announced that enrollment has been completed in a randomized Phase II study of REOLYSIN^® in patients with previously treated advanced or metastatic non-small cell lung cancer. [Oncolytics Biotech^® Inc.] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Cancer and Molecular Imaging (University of Michigan)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Senior Research Technician (Qu Biologics Inc.)

Postdoctoral Research Associate – Airway Diseases (GlaxoSmithKline)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Fellow – Biotechnology (Qu Biologics Inc.)

Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Fellow – Cancer Research (National University of Singapore)

PhD Studentships – Pulmonary Biology and Medicine (University of Giessen Lung Center)

Postdoctoral Fellow – Pulmonary Fibrosis (University of Colorado School of Medicine)

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