4-Hydroxynonenal Regulates Mitochondrial Function in Human Small Airway Epithelial Cells Scientists explored the effects of 4-hydroxynonenal (4-HNE) in human small airway epithelial cells (SAECs). Human SAECs treated with 25 μM of 4-HNE showed a significant decrease in cellular viability and increased caspase-3 activity. [Oncotarget] Full Article Bombesin Receptor-Activated Protein (BRAP) Modulates NF-κB Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity The authors demonstrated that BRAP has a regulatory effect on NF-κB transcriptional activity in cultured human bronchial epithelial cells (HBECs). BRAP overexpression by gene transfer inhibited both basal and inducible NF-κB transcriptional activity in HBECs, whereas BRAP knockdown had the opposite effect. [J Cell Biochem] Abstract Normal and Cystic Fibrosis Human Bronchial Epithelial Cells Infected with Pseudomonas aeruginosa Exhibit Distinct Gene Activation Patterns To identify the molecular determinants of an effective response to P. aeruginosa infection, scientists performed a transcriptomic analysis of primary human bronchial epithelial cells from healthy donors two, four, and six hours after induced P. aeruginosa infection. [PLoS One] Full Article Anti-Inflammatory Effects of Resveratrol on Hypoxia/Reoxygenation–Induced Alveolar Epithelial Cell Dysfunction The authors demonstrated resveratrol-mediated reversal of hypoxia-reoxygenation-induced inflammatory responses and dysfunction of type II pneumocyte cells in vitro. [J Agric Food Chem] Abstract | Graphical Abstract LUNG CANCER pH Sensitive Nano Layered Double Hydroxides Reduce the Hematotoxicity and Enhance the Anticancer Efficacy of Etoposide on Non-Small Cell Lung Cancer The functions of layered double hydroxides (LDH) carrying etoposide (VP16) on non-small cell lung cancer were explored both in vitro and in vivo. In A549 cell line, LDH-VP16 induced apoptosis 2.3-fold as that of plain VP16 by targeting to mitochondrial, stocking cells in G1 phase. [Acta Biomater] Abstract miR-342-3p Regulates MYC Transcriptional Activity via Direct Repression of E2F1 in Human Lung Cancer The authors attempted to identify miRNAs involved in regulation of MYC transcriptional activity in lung cancer. To this end, they utilized an integrative approach with combinatorial usage of miRNA and mRNA expression profile datasets of patient tumor tissues, as well as those of MYC-inducible cell lines in vitro. [Carcinogenesis] Abstract Role of miR-497 in VEGF-A-Mediated Cancer Cell Growth and Invasion in Non-Small Cell Lung Cancer Researchers showed that compared to other cancers, non-small cell lung cancer (NSCLC) had a significant higher ratio of vascular endothelial growth factor A (VEGF-A) protein vs mRNA, and significantly lower levels of miR-497, suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers. [Int J Biochem Cell Biol] Abstract c-Myc-Regulated Long Non-Coding RNA H19 Indicates a Poor Prognosis and Affects Cell Proliferation in Non-Small-Cell Lung Cancer Researchers assessed the biological role of long non-coding RNA H19 in non-small-cell lung cancer (NSCLC). Knockdown of H19 significantly inhibited NSCLC cell proliferation both in vitro and in vivo. [Tumor Biol] Abstract The Regulatory and Predictive Functions of miR-17 and miR-92 Families on Cisplatin Resistance of Non-Small Cell Lung Cancer Abnormal expressions of miR-17 and miR-92 families were observed in cisplatin-resistant cells, suggesting that miR-17 and miR-92 families are involved in the regulation of cisplatin resistance in non-small cell lung cancer. [BMC Cancer] Full Article |