Pulmonary Cell News Volume 4.46 | Nov 26 2015

Nuclear Factor κB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels
The authors cultured immortalized human bronchial epithelial cells at ambient atmospheric, 21% O₂ and 10% O₂. They reported increased inflammatory response at 21% O₂ but not at 10% O₂. [J Cell Physiol] Abstract

Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells
Scientists examined production of antiviral cytokine interferon-β and inflammatory chemokine interleukin-8, expression of the interferon-responsive antiviral gene 2’-5’-oligoadenylate synthetase 1, and intracellular virus RNA load in primary cystic fibrosis and healthy airway epithelial cells following inoculation with human rhinovirus 16. [PLoS One] Full Article

Mesenchymal Stem Cell Conditioned Medium Promotes Proliferation and Migration of Alveolar Epithelial Cells under Septic Conditions In Vitro via the JNK-P38 Signaling Pathway
Researchers investigated the impact of human umbilical cord Wharton’s jelly-derived mesenchymal stem cell secreted factors on alveolar epithelial cells under septic conditions and determined the relevant intracellular signaling pathways. [Cell Physiol Biochem] Full Article

Expression of Nodal on Bronchial Epithelial Cells Influenced by Lung Microbes Through DNA Methylation Modulates the Differentiation of T-Helper Cells
Investigators showed that Nodal promoted proliferation of bronchial epithelial cells (BECs) and BEC-induced differentiation of T-helper (Th) cell from Th1 to Th2 and Th17. [Cell Physiol Biochem] Full Article

LUNG CANCER

Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer
To identify potential biomarkers of response and mechanisms of polo-like kinase 1 (PLK1) inhibitor-induced apoptosis, scientists performed an integrated analysis of gene and protein expression, gene mutation, and drug sensitivity using three PLK1 inhibitors in a large panel of non-small cell lung cancer cell lines. [Clin Cancer Res] Abstract

TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins
The authors report that TRIM59 protein was significantly increased in various non-small cell lung cancer (NSCLC) cell lines. siRNA-induced knocking down of TRIM59 significantly inhibited the proliferation and migration of NSCLC cell lines by arresting cell cycle in G2 phase. [PLoS One] Full Article

Antitumor Effects of Deguelin on H460 Human Lung Cancer Cells In Vitro and In Vivo: Roles of Apoptotic Cell Death and H460 Tumor Xenografts Model
Scientists investigated the effect of deguelin on apoptotic pathways in human lung cancer cells and the anti-tumor effect in lung cancer xenograft nu/nu mice. [Environ Toxicol] Abstract

Lentivirus-Mediated Knockdown of CTDP1 Inhibits Lung Cancer Cell Growth In Vitro
Investigators explored the roles of CTDP1 in the progression of human lung cancer. Inhibition of CTDP1 expression significantly suppressed cell growth, induced G0/G1 phase arrest and repressed cell colony formation [J Cancer Res Clin Oncol] Abstract

Radiosensitizing Effect of PSMC5, a 19S Proteasome ATPase, in H460 Lung Cancer Cells
Researchers identified proteasome 26S subunit, ATPase 5 (PSMC5) as a novel radiosensitivity biomarker, demonstrating that radiosensitive H460 cells were converted to a radioresistance phenotype by PSMC5 depletion. [Biochem Biophys Res Commun] Abstract

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FDA Approves Portrazza™ (Necitumumab) for Specific Type of Lung Cancer
Eli Lilly and Company announced that the U.S. Food and Drug Administration (FDA) has approved Portrazza™, in combination with gemcitabine and cisplatin, as the first biologic for the first-line treatment of people with metastatic squamous non-small cell lung cancer. [Eli Lilly and Company] Press Release

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Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Postdoctoral Fellow – Cancer Biology (Cold Spring Harbor Laboratory)

Professorship – Respiratory Science (University of Cambridge)

Postdoctoral Positions – Fibrotic Remodeling of the Lung (University of Vermont)

Postdoctoral Positions – Cancer (University of Texas MD Anderson Cancer Center)

Post-Doctoral Fellow – Lung Microbiome Research and Asthma (University of Michigan)

Postdoctoral Position – Lung Biology Research (University of Southern California)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Researcher – Molecular Mechanisms of Pulmonary Diseases (Eastern Virginia Medical School)

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