Pulmonary Cell News Volume 5.10 | Mar 17 2016

Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells
Using mouse E10 cells as an alveolar type I cell cell model, scientists demonstrated that higher hemoglobin (Hb) oxidation states ferric and ferryl Hb and subsequent heme loss play a central role in the genesis of injury. [Am J Respir Cell Mol Biol] Abstract

β1-Na⁺,K⁺-ATPase Gene Therapy Upregulates Tight Junctions to Rescue Lipopolysaccharide-Induced Acute Lung Injury
Gene transfer of β1-Na⁺,K⁺-ATPase, but not α1-subunit of epithelial sodium channel, not only enhanced expression of tight junction protein zona occludins-1 and occludin both in cultured cells and in mouse lungs, but also reduced pre-existing increase of lung permeability in vivo. [Gene Ther] Abstract

Dipeptidyl Peptidase-4 Is Highly Expressed in Bronchial Epithelial Cells of Untreated Asthma and It Increases Cell Proliferation along with Fibronectin Production in Airway Constitutive Cells
Researchers investigated the expression of dipeptidyl peptidase-4 in the asthmatic airway, and its role in the pathophysiology of asthma. [Respir Res] Full Article

Human H7N9 Virus Induces a More Pronounced Pro-Inflammatory Cytokine but an Attenuated Interferon Response in Human Bronchial Epithelial Cells when Compared with an Epidemiologically-Linked Chicken H7N9 Virus
The authors previously isolated an H7N9 virus from a patient, and an H7N9 virus from a chicken in a live poultry market where the patient visited during the incubation period. These two viruses were genetically highly similar. This study sought to use a human bronchial epithelial cell line model to infer the virulence of these H7N9 viruses in humans. [Virol J] Full Article

LUNG CANCER

APR-246 (PRIMA-1^MET) Strongly Synergizes with AZD2281 (Olaparib) Induced PARP Inhibition to Induce Apoptosis in Non-Small Cell Lung Cancer Cell Lines
Scientists observed that APR-246 synergistically enhanced the cytotoxic response of olaparib in TP53 mutant non-small cell lung cancer cell lines, resulting in a strong apoptotic response. [Cancer Lett] Abstract

Overexpression of miR-499-5p Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis by Targeting VAV3
Researchers demonstrated that miR-499-5p was significantly reduced in NSCLC tissues and correlated with poor clinical outcomes. Overexpression of miR-499-5p inhibited cell proliferation and induced apoptosis in vitro and in vivo. [Sci Rep] Full Article

hnRNPK Inhibits GSK3β Ser9 Phosphorylation, Thereby Stabilizing c-FLIP and Contributes to TRAIL Resistance in H1299 Lung Adenocarcinoma Cells
Investigators showed that, when H1299 lung adenocarcinoma cells were treated with TRAIL, hnRNPK is translocated from nucleus to cytoplasm where it interacts and co-localizes with GSK3β. [Sci Rep] Full Article

Periostin Contributes to Cisplatin Resistance in Human Non-Small Cell Lung Cancer A549 Cells via Activation of Stat3 and Akt and Upregulation of Survivin
Periostin was significantly upregulated in cisplatin (CDDP)-resistant A549 cells, compared to parental controls. Overexpression of periostin rendered A549 cells more resistant to CDDP-induced apoptosis and enhanced Stat3 and Akt phosphorylation and survivin expression. [Cell Physiol Biochem] Full Article

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Aradigm Announces Decision for Centralized Review of Pulmaquin by the European Medicines Agency
Aradigm Corporation announced that the European Medicines Agency has approved its request to review Pulmaquin^®, Aradigm’s investigational inhaled liposomal ciprofloxacin product, under the Centralised Authorisation Procedure drug review process. [Aradigm Corporation] Press Release

SRI International Receives $19.8 Million National Cancer Institute Contract for PREVENT Cancer Program
SRI International has been awarded a contract of up to $19.8 million from the National Cancer Institute PREVENT Cancer Preclinical Drug Development Program to support the development of potential cancer preventive agents or vaccines. [SRI International] Press Release

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Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

Faculty Positions – Cancer Research (Texas Tech University Health Sciences Center)

Postdoctoral Fellow – Lung Cancer (The University of Texas MD Anderson Cancer Center)

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