Pulmonary Cell News 6.23 June 15, 2017 | |
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TOP STORYScientists Discover Cause of Deadly Syndrome after Lung Transplantation Scientists discovered that a subset of immune cells called nonclassical monocytes, previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction, the leading cause of death after lung transplantation. [Press release from Northwestern University discussing online prepublication in Science Translational Medicine] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Protective and Therapeutic Effect of Felodipine against Bleomycin-Induced Pulmonary Fibrosis in Mice Investigators screened for chemicals capable of inhibiting transforming growth factor-β1-induced collagen production in cultured fibroblasts from medicines already in clinical use. They selected felodipine based on its extent of collagen production inhibition, clinical safety profile, and other pharmacological activity. Intratracheal administration of felodipine prevented bleomycin-induced pulmonary fibrosis, alteration of lung mechanics and respiratory dysfunction. [Sci Rep] Full Article Researchers systematically evaluated the pharmacodynamic and pharmacokinetic performance of pulmonary rehabilitation mixture (PRM). The pharmacodynamic results showed that PRM could improve the condition of CoCl2-stimulated human type II alveolar epithelial cells, human pulmonary microvascular endothelial cells, human lung fibroblasts and pulmonary fibrosis rats induced by bleomycin. [Sci Rep] Full Article Scientists aimed to define the role of alveolar progenitor type II cell (ATIIC)-derived exosome miRNA signaling in controlling ATIIC-specific proliferation or differentiation in response to injury. They showed that human ATIIC line-derived exosome miR-371b-5p promoted ATIIC-specific proliferation, but not differentiation, in differentiating cultures of pluripotent stem cells. [Stem Cell Res Ther] Full Article Investigators observed that cigarette smoke extract (CSE) induced a successive expression of early growth response factor 1 (Egr-1) and MUC5AC in human bronchial epithelial cells. Knockdown of Egr-1 markedly attenuated CSE-induced MUC5AC production, and chromatin immunoprecipitation revealed that Egr-1 transcriptionally bound to MUC5AC promoter upon CSE stimulation. [Biochem Biophys Res Commun] Abstract LUNG CANCERThe authors provide evidence for programmed cell death protein 1 (PD-L1) induction in response to lactate stimulation in lung cancer cells. Lactate-induced PD-L1 induction was mediated by its receptor GPR81. The silencing of GPR81 signaling in lung cancer cells resulted in a decrease in PD-L1 protein levels and functional inactivation of PD-L1 promoter activity. [Oncogene] Abstract In a conditional Tp53;Rb1 mutant mouse model of SCLC, researchers demonstrated a requirement for the hedgehog ligand Sonic hedgehog (Shh) for the progression of SCLC. They showed that overexpression of cyclin B1 induced chromosomal instability in mouse embryonic fibroblasts lacking both Tp53 and Rb1. [Oncogene] Full Article Scientists report that miR-137 is downstream of the epithelial-mesenchymal transition (EMT) regulator, Slug, in lung cancer cells. Slug bound directly to the E-box of the miR-137 promoter and up-regulated its expression in lung cancer cells. Knockdown of miR-137 abolished Slug-induced cancer invasion and migration, whereas upregulation of miR-137 was found to trigger lung cancer cell invasion and progression by direct suppressing transcription factor AP-2 gamma (TFAP2C). [Cancer Lett] Abstract Feedback Regulation of ALDOA Activates the HIF-1α/MMP9 Axis to Promote Lung Cancer Progression Investigators analyzed integrated transcriptomics data and an shRNA library against glycolytic enzymes and found that elevated Aldolase A expression is highly correlated with metastatic potential and a poor prognosis in patients with NSCLC. Aldolase A silencing significantly suppressed metastatic potential both in vitro and in vivo, whereas the ectopic overexpression of Aldolase A resulted in the opposite phenotype. [Cancer Lett] Abstract Researchers found that flavonoids including kaempferol, chrysin, and luteolin concentration-dependently decrease claudin-2 expression in lung adenocarcinoma A549 cells. Promoter deletion assay using luciferase reporter vector showed that kaempferol and luteolin inhibited the function of transcriptional factor that binds to the region between -395 and -144 of claudin-2 promoter. The decrease in promoter activity was suppressed by mutation in signal transducers and activators of transcription (STAT)-binding site, which is located between -395 and -144. [Nutrients] Full Article | |
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REVIEWSTargeting EIF4F Complex in Non–Small Cell Lung Cancer Cells The authors summarize recent findings regarding the role of EIF4F complex in NSCLC progression and targeted therapy potentials. They also discuss the unanswered questions and future directions in this field. [Oncotarget] Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSOSE Immunotherapeutics SA announced that the company has entered into a multi-year research collaboration on OSE-703, a cytotoxic monoclonal antibody against the alpha chain of interleukin-7 receptor, with Memorial Sloan Kettering Cancer Center in New York. The goal of this research collaboration is to explore IL-7R directed immunotherapy OSE-703 for solid tumors with NSCLC as the primary cancer model. [OSE Immunotherapeutics SA] Press Release Center to Advance Tissue Regeneration, Stem Cell Discoveries The University of Illinois College of Medicine launched a new center that focuses on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues. Researchers in the new center will investigate the molecular signals that drive stem cells to mature into different cell types, such as blood, heart and blood vessel cells. [University of Illinois] Press Release | |
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POLICY NEWSTexas Has Sanctioned Unapproved Stem Cell Therapies. Will It Change Anything? Texas Governor Greg Abbott signed a bill allowing clinics and companies in the state to offer people unproven stem cell interventions without the testing and approval required under federal law. Like the “right to try” laws that have sprung up in more than 30 states, the measure is meant to give desperately ill patients access to experimental treatments without oversight from the U.S. Food and Drug Administration. [ScienceInsider] Editorial Empty Rhetoric over Data Sharing Slows Science Government agencies lack the funds to build platforms for data sharing and resist taking responsibility for such infrastructure. They may hope that universities will host data, but the development of institutional repositories is patchy, and to rely on them is effectively to discourage common data standards and curation. [Nature News] Editorial Can Fake Names Tease Out NIH Reviewer Bias? When the label “white male” is attached to a research grant application, do peer reviewers give it a better score? That’s the question psychologist Patricia Devine of the University of Wisconsin in Madison has spent the past four years, and more than $1 million from the National Institutes of Health (NIH) in Bethesda, Maryland, trying to answer with an unusual experiment. [ScienceInsider] Editorial Curiosity and Irritation Meet Macron’s Effort to Lure Foreign Scientists to France The French government unveiled a website aimed at attracting foreign scientists with four-year grants worth up to €1.5 million each. [ScienceInsider] Editorial
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EVENTSNEW AACR-NCI-EORTC Molecular Targets & Cancer Therapeutics Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Training – Lung Disease (Baylor College of Medicine) NEW Research Fellow – Cancer Research (National University of Singapore) Staff Research Scientist – Lung Injury (St. Michael’s Hospital) Postdoctoral Researcher – Lung Cancer Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Researcher – Inhalation & Developmental Toxicology (Louisiana State University) Faculty – Immunology of Lung Diseases (National Jewish Health) Research Administrator IV – Early Detection of Lung Cancer (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Pulmonary Cell News Volume 6.23 | Jun 15 2017