Pulmonary Cell News Volume 6.27 | Jul 13 2017

TOP STORY

LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LDS1 Interactions with SNAG Domain Proteins INSM1 and GFI1B

The authors describe the anti-cancer effects and mechanism of action of T-3775440 in small cell lung cancer (SCLC). T-3775440 inhibited proliferation of SCLC cells in vitro and retarded SCLC tumor growth in vivo. [Cancer Res] Abstract

(Ranked by impact factor of the journal)

Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury

The authors describe a TGFβ-triggered mechanism, in which megalin, the primary mediator of alveolar protein transport, is negatively regulated by GSK3β, with protein phosphatase 1 (PP1) and nuclear inhibitor of PP1 being involved in the signaling cascade. Inhibition of GSK3β rescued transepithelial protein clearance in primary alveolar epithelial cells after TGFβ treatment. [Am J Respir Cell Mol Biol] Abstract

Single-Cell RNA Sequencing Reveals an Altered Gene Expression Pattern as a Result of CRISPR/Cas9-Mediated Deletion of Gene 33/Mig6 and Chronic Exposure to Hexavalent Chromium in Human Lung Epithelial Cells

Scientists used single-cell RNA sequencing to compare gene expression profiles between BEAS-2B lung epithelial cells chronically exposed to a sublethal dose of Cr(VI) with or without CRISPR/cas9-mediated deletion of Gene 33. [Toxicol Appl Pharmacol] Abstract

MicroRNA-155 Regulates Arsenite-Induced Malignant Transformation by Targeting Nrf2-Mediated Oxidative Damage in Human Bronchial Epithelial Cells

Human bronchial epithelial cells were continuously exposed to 2.5 μM arsenite for about 13 weeks to induce the phenotypes of malignant transformation. They showed that Nrf2 expression was gradually decreased whereas no significant change was observed on NF-κB activation with increased time of arsenite exposure. [Toxicol Lett] Abstract

Stress Fibers, Autophagy and Necrosis by Persistent Exposure to PM_2.5 from Biomass Combustion

Potential molecular consequences were investigated during long-term exposure of human bronchial epithelial BEAS-2B cells to fine particulate matter (PM_2.5), collected from a biomass power plant. [PLoS One] Full Article

Receptor for Advanced Glycation Endproducts (RAGE) Maintains Pulmonary Structure and Regulates the Response to Cigarette Smoke

Primary murine alveolar epithelial cells isolated from RAGE^-/- mice revealed an altered differentiation and defective barrier formation under in vitro conditions. [PLoS One] Full Article

LUNG CANCER

Suberoylanilide Hydroxamic Acid Induces Thioredoxin1-Mediated Apoptosis in Lung Cancer Cells via Up-Regulation of miR-129-5p

Researchers investigated the effect of suberoylanilide hydroxamic acid on apoptosis in lung cancer cells and addressed the role of reactive oxygen species, glutathione, and thioredoxin1 levels in this process. [Mol Carcinog] Abstract

β-Elemene Regulates Endoplasmic Reticulum Stress to Induce the Apoptosis of NSCLC Cells through PERK/IRE1α/ATF6 Pathway

The potential effect and underlying mechanisms of β-elemene on regulating endoplasmic reticulum stress to inhibit NSCLC are still unclear. A549 cells and Lewis tumor-bearing C57BL/6J mice were established to evaluate this effect. [Biomed Pharmacother] Abstract

Andrographolide Enhances Cisplatin-Mediated Anticancer Effects in Lung Cancer Cells through Blockade of Autophagy

Researchers found that cisplatin induced autophagy that attenuated the sensitivity of both A549 and Lewis lung cancer cells to cisplatin. In contrast, the clinical drug andrographolide suppressed autophagy and enhanced cisplatin-mediated apoptosis in these cells. [Anticancer Drugs] Abstract

Extracellular Vesicles in Lung Disease

Accumulating evidence suggests that extracellular vesicles play a role in pathogenesis of lung diseases. The vesicles include exosomes, ectosomes, and apoptotic bodies. Exosomes are generated by inward budding of the membrane, subsequent forming multivesicular bodies, and releasing by exocytosis. [Chest] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

CRISPR Therapeutics and Neon Therapeutics Enter Research Collaboration

CRISPR Therapeutics and Neon Therapeutics announced a research collaboration to explore the combination of each company’s proprietary technologies to develop novel T cell therapies. [CRISPR Therapeutics] Press Release

Regen BioPharma, Inc. Researchers Discover New Dynamic Compound Which Modulates the NR2F6 Checkpoint

Regen BioPharma Inc. reported continued progress in developing small molecule drugs that activate and inhibit NR2F6. The NR2F6 nuclear receptor has been identified as a potentially very important immune cell inhibitor and cancer stem cell differentiator. [Regen BioPharma Inc. (PR Newswire Association LLC.)] Press Release

US Lawmakers Seek $1.1 Billion Boost for the NIH

The US National Institutes of Health (NIH) would see its budget rise by US$1.1 billion in 2018, to $35.2 billion, under a spending proposal released by lawmakers in the House of Representatives. [Nature News] Editorial

Marketing of Unproven Stem Cell–Based Interventions: A Call to Action

Commercial promotion of unsupported therapeutic uses of stem cells is a global problem that has proven resistant to regulatory efforts. The authors suggest a coordinated approach at the national and international levels focused on engagement, harmonization, and enforcement to reduce the risks associated with direct-to-consumer marketing of unproven stem cell treatments. [Sci Transl Med] Abstract | Editorial

In a Rare Move, FDA Reverses Course on Drug Developed by CEO with Ties to Trump

The Food and Drug Administration has changed its tune on an experimental drug for a deadly rare disease, withdrawing a request that the company developing it run another clinical trial. The unusual move comes after President Trump met with the company’s CEO — and promised to speed up what he called a “slow and burdensome” process for drug approvals. [STAT news] Editorial

NEW AACR-NCI-EORTC International Conference on Molecular Targets & Cancer Therapeutics
November 5-9, 2017
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Cell Signaling/Cancer Biology (Rutgers Cancer Institute of New Jersey)

NEW Postdoctoral Fellow – Allergy and Immunology (New York University Medical Center)

Senior Scientist – Lung Repair and Regeneration (AstraZeneca)

Postdoctoral Fellow – Pathogenesis of Lung Diseases (Oklahoma State University)

Postdoctoral Fellow – Lung Microengineering (University of Colorado)

PhD Position – Lung Disease (Helmholtz Zentrum München)

Postdoctoral Associate – Lung Cancer Research (Weill Cornell Medicine)

Research Fellow – Cancer Research (National University of Singapore)

Staff Research Scientist – Lung Injury (St. Michael’s Hospital)

Postdoctoral Research Scientist – miRNAs in Differentiation of Lung Progenitor Cells (Columbia University)

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