Pulmonary Cell News Volume 6.49 | Dec 14 2017

TOP STORY

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

Scientists report that a glutaminolytic enzyme, glutamate dehydrogenase 1 (GDH1), upregulated upon detachment via pleomorphic adenoma gene 1 (PLAG1), provided anti-anoikis and pro-metastatic signals in LKB1-deficient lung cancer. [Mol Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Enhancement of Glycolysis by Inhibition of Oxygen-Sensing Prolyl Hydroxylases Protects Alveolar Epithelial Cells from Acute Lung Injury

The authors evaluated the effects of pharmacological prolyl hydroxylase inhibition with dimethyloxalylglycine on alveolar epithelial cell injury using in vitro and in vivo acute respiratory distress syndrome models. [FASEB J] Abstract

circHIPK2-Mediated σ-1R Promotes Endoplasmic Reticulum Stress in Human Pulmonary Fibroblasts Exposed to Silica

Both molecular biological assays and pharmacological techniques, combined with functional experiments, such as migration and proliferation, were applied in human pulmonary fibroblasts from adults to analyze the molecular and functional changes induced by SiO₂. [Cell Death Dis] Full Article

Cigarette Smoke and Non-Neuronal Cholinergic System in the Airway Epithelium of COPD Patients

Acetylcholine (ACh), synthesized by choline acetyl-transferase (ChAT), exerts its physiological effects via mAChRM3 in epithelial cells. Cigarette smoke modified the levels of mAChMR3, ChAT expression, and ACh production in bronchial epithelial cells from COPD patients. [J Cell Physiol] Abstract

The Isoprenoid End Product N6-Isopentenyladenosine Reduces Inflammatory Response through the Inhibition of the NFκB and STAT3 Pathways in Cystic Fibrosis Cells

Researchers demonstrated that N6-isopentenyladenosine prevents interleukin-8 and RANTES release in TNFα-stimulated CF cells and this effect is mediated by increasing the expression of the direct NFκB inhibitor IκBα and decreasing the levels of STAT3. [Inflamm Res] Full Article

LUNG CANCER

Activation of the Aryl Hydrocarbon Receptor Leads to Resistance to EGFR TKIs in Non-Small-Cell Lung Cancer by Activating Src-Mediated Bypass Signaling

Inhibition of aryl hydrocarbon receptor (AhR) signaling sensitized epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer cells that express high level of endogenous AhR protein. [Clin Cancer Res] Abstract | Full Article

miR-124 Inhibits Growth and Enhances Radiation-Induced Apoptosis in Non-Small Cell Lung Cancer by Inhibiting STAT3

Investigators found that miR-124 was downregulated both in clinical non-small-cell lung carcinoma (NSCLC) samples and in cell lines. miR-124 inhibited the proliferation of NSCLC cells and enhanced the apoptosis of NSCLC cells exposed to ionizing radiation. [Cell Physiol Biochem] Full Article

MicroRNA-128-3p-Mediated Depletion of Drosha Promotes Lung Cancer Cell Migration

Scientists showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. They observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells. [Carcinogenesis] Abstract

Effect of CDK1 shRNA on Proliferation, Migration, Cell Cycle and Apoptosis in Non-Small Cell Lung Cancer

CDK1 knockdown inhibited cell growth, proliferation, migration, retarded cell cycle and accelerated cell apoptosis. By downregulating cyclin B, cyclin D1 and Bcl-2, CDK1 inhibited the progression of non-small cell lung cancer. [J Cell Physiol] Abstract

Netrin-1 Elicits Metastatic Potential of Non-Small Cell Lung Carcinoma Cell by Enhancing Cell Invasion, Migration and Vasculogenic Mimicry via EMT Induction

Netrin-1 had relatively high expression in non-small cell lung cancer (NSCLC) tissues and cells, especially in high metastatic groups. Notably, netrin-1 overexpression aggravated the malignant metastatic behavior of NSCLC cells, including cell invasion, migration, and vasculogenic mimicry, whereas netrin-1 depression reversely dampened the metastatic potential. [Cancer Gene Ther] Abstract

TGFβ as a Therapeutic Target in Cystic Fibrosis

Scientists discuss CF lung disease pathogenesis with a focus on potential links to transforming growth factor beta (TGFβ). [Expert Opin Ther Targets] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

AbilityPharma Announces FDA Approval of IND for Phase II Trial of ABTL0812 in Patients with Endometrial Cancer or Squamous Non-Small Cell Lung Cancer

Ability Pharmaceuticals SL announced that FDA has accepted the Investigational New Drug (IND) application which validates the Phase I/IIa clinical trial of ABTL0812, its autophagy PI3K/Akt/mTOR pathway inhibitor, in patients with endometrial cancer or squamous non-small cell lung cancer, in combination with paclitaxel and carboplatin as first-line therapy. [Ability Pharmaceuticals SL] Press Release

Prometic’s PBI-4050 Receives Promising Innovative Medicine (PIM) Designation from the UK MHRA in the Treatment of Idiopathic Pulmonary Fibrosis

Prometic Life Sciences Inc. announced that its orally-active drug candidate, PBI-4050, has been issued a PIM designation by the UK Medicines and Healthcare Products Regulatory Agency (MHRA) as add-on treatment to nintedanib in patients with idiopathic pulmonary fibrosis. [Prometic Life Sciences Inc.] Press Release

French Researchers Hope New Chief Will Revitalize Troubled Funding Agency

French scientists are hopeful that the newly appointed chief of a major research-funding agency will revive an organization suffering from squeezed budgets and staff discontent. [Nature News] Editorial

Iran’s Supreme Court Confirms Death Sentence for Jailed Scholar

Iran’s Supreme Court has upheld the death sentence handed to Ahmadreza Djalali, a scholar who worked in Europe, according to the human-rights group Amnesty International. [Nature News] Editorial

NEW The London Stem Cell Network Symposium 2018
February 26, 2018
London, United Kingdom

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NEW Scientific Officer – Lung Cancer (CRUK Manchester Institute)

NEW Postdoctoral Position – Cell Signaling and Cell Differentiation (Stanford University)

NEW Postdoctoral Researcher – Cancer Research (University of California, Davis)

Postdoctoral Fellow – Human Airway Stem Cell Biology (Cornell University)

PhD Studentship – Heterogeneity in Small Cell Lung Cancer (CRUK Manchester Institute)

Postdoctoral Fellow/Associate – Inflammation and Fibrosis (Rhode Island Hospital)

Postdoctoral Position – Lung Cancer (Helmholtz Centre for Environmental Research)

Postdoctoral Fellow – Disease Mechanism (University of California, San Diego)

Postdoctoral Fellow – Lung Cancer (Moffitt Cancer Center)

Postdoctoral Position – Immunology & Respiratory Diseases (Boehringer Ingelheim)

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