Pulmonary Cell News 7.03 January 25, 2018 | |
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TOP STORYScientists showed, in the context of influenza virus infection of lung epithelial cells, that silver nanoparticles down-regulated influenza induced-CCL-5 and -IFN-β release through RIG-I inhibition, while enhancing IL-8 production, a cytokine important for mobilizing host antibacterial responses. [ACS Nano] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Previous studies localized the hedgehog (HH) signaling system to primary cilia. Investigators discovered that motile cilia on airway epithelia also contain HH signaling proteins, indicating that like primary cilia, these motile cilia have an important sensory function. [Proc Natl Acad Sci USA] Full Article The authors found that IFN-γ rapidly induced Noxa expression and that the extent of inflammation by repeated house dust mite exposure was enhanced in noxa−/− compared with noxa+/+ mice. [Mucosal Immunol] Abstract Researchers showed that activating transcription factor 3 (ATF3), a member of the integrated stress response, negatively regulates transcription of the PTEN-induced putative kinase 1 (PINK1) gene. [Aging Cell] Full Article Scientists observed the effects of nuclear factor erythroid 2-related factor (2Nrf2) pathway and Numb on bleomycin-induced pulmonary fibrosis in Nrf2-knockout and wild-type mice. [Cell Death Dis] Full Article LUNG CANCERIκB kinase α (IKKα) ablation turned the antitumorigenic effect of Kras-induced reactive oxygen species to a protumorigenic effect that enhances Kras-induced progression of lung adenocarcinoma. [Proc Natl Acad Sci USA] Full Article Researchers observed that MEK inhibition induced feedback activation of the receptor tyrosine kinase (RTK) EGFR, and in some cases the RTK FGFR, resulting in transient suppression of ERK phosphorylation in BRAF non-V600E, but not BRAF V600E, mutant cells. [Oncogene] Abstract The authors report that overexpression of a glycolytic enzyme, phosphoglyceric acid mutase-1 (PGAM1), is critical to oncogenic mechanistic target of rapamycin (mTOR)-mediated Warburg effect. mTOR stimulated PGAM1 expression through hypoxia-inducible factor 1α-mediated transcriptional activation. [Cell Death Differ] Full Article Investigators report that HOXA transcript at the distal tip (HOTTIP), encoding a long non-coding RNA that is frequently amplified in small cell lung cancer (SCLC), was associated with SCLC cell chemosensitivity, proliferation, and poor prognosis of SCLC patients. [Cell Death Dis] Full Article Scientists present a highly sensitive immunomagnetic separation method to capture circulating tumor cells based on two cell surface markers for non-small cell lung cancer, epithelial cell adhesion molecule (EpCAM) and folate receptor alpha (FRα). [Sci Rep] Full Article | |
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REVIEWSThe Biology and Management of Non-Small Cell Lung Cancer Important advancements in the treatment of non-small cell lung cancer have been achieved over the past two decades, increasing our understanding of the disease biology and mechanisms of tumor progression, and advancing early detection and multimodal care. [Nature] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSBiomarck Pharmaceuticals, Ltd announced that a Phase II clinical study in advanced NSCLC has commenced. This trial will evaluate the safety and efficacy of Biomarck’s novel, patented, MARCKS protein inhibitor. [Biomarck Pharmaceuticals, Ltd (PR Newswire Association LLC)] Press Release Amgen and Allergan plc. announced that the European Commission has granted marketing authorization for MVASI®. [Amgen Inc.] Press Release | |
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POLICY NEWSGerman Scientists Hope for Windfall from Incoming Government Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial Nobel Laureate Suggests He Could Fall on Sword over Colleague’s Bogus Paper Shinya Yamanaka, who won a share of the 2012 Noble Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application in Japan over a fraudulent paper published by center researchers. [ScienceInsider] Editorial
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EVENTSNEW Cold Spring Harbor (CSH): Mechanisms & Models of Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Lung Cancer (Van Ande Research Institute) Postdoctoral Position – Biomedical Systems Biology (University of Zurich) Postdoctoral Scholarship – Translational Cancer Stem Cell Biology (Lund University) Postdoctoral Position – Pulmonary Disease Pathogenesis (Columbia University) Postdoctoral Training Fellow – Lung Cancer (The Francis Crick Institute) Postdoctoral Fellow – Lung Regeneration after Injury (University of Michigan) Postdoctoral Fellow – Lung Cancer (MD Anderson Cancer Center) Postdoctoral Position – Cell Signaling and Cell Differentiation (Stanford University) Postdoctoral Researcher – Cancer Research (University of California, Davis) Postdoctoral Fellow – Human Airway Stem Cell Biology (Cornell University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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