Pulmonary Cell News Volume 7.22 | Jun 7 2018

TOP STORY

PHIP as a Therapeutic Target for Driver-Negative Subtypes of Melanoma, Breast, and Lung Cancer

Investigators showed that pleckstrin homology domain-interacting protein (PHIP) promotes the progression of “driver-negative” tumors. Suppression of PHIP expression significantly inhibited both tumor cell proliferation and invasion, coordinately suppressing phosphorylated AKT, cyclin D1, and talin1 expression in all three tumor types. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

Quantifying Ciliary Dynamics during Assembly Reveals Step-Wise Waveform Maturation in Airway Cells

Researchers analyzed cilia motion from high-speed video microscopy of ciliated cells sampled from human lung airways compared to primary-culture cells that underwent ciliogenesis in vitro. [Am J Respir Cell Mol Biol] Abstract

Rapid Clearance of Heavy Chain-Modified Hyaluronan during Resolving Acute Lung Injury

Scientists assessed tumor necrosis factor α (TNFα)-stimulated-gene-6 secretion by TNFα- or lipopolysaccharide-stimulated human alveolar macrophages, lung fibroblast Wi38, and bronchial epithelial BEAS-2B cells. [Respir Res] Full Article

MicroRNA-21 Mediates the Protective Effects of Mesenchymal Stem Cells Derived from iPSCs to Human Bronchial Epithelial Cell Injury under Hypoxia

The human bronchial epithelial cell line BEAS-2B was induced to undergo apoptosis with a hypoxia mimic of cobalt chloride damage. Treatment of mesenchymal stem cells derived from induced pluripotent stem cells (iPSCs) significantly decreased apoptosis of BEAS-2B cells. [Cell Transplant] Full Article

Butylated Hydroxytoluene Induces Type-V Collagen and Overexpression of Remodeling Genes/Proteins in Experimental Lung Fibrosis

Investigators analyzed whether butylated hydroxytoluene alters distal airway/alveolar epithelial cells and extracellular matrix signaling involved in the initiation and progression of pulmonary fibrosis in a different pathway concerning overexpression of type-V collagen. [Histol Histopathol] Abstract

LUNG CANCER

FGFR1-ERK1/2-SOX2 Axis Promotes Cell Proliferation, Epithelial-Mesenchymal Transition, and Metastasis in FGFR1-Amplified Lung Cancer

Researchers showed that activation of fibroblast growth factor receptor 1 (FGFR1) by its ligand fibroblast growth factor 2 promoted proliferation, epithelial-mesenchymal transition, migration, and invasion in FGFR1-amplified lung cancer cell lines H1581 and DMS114, whereas inhibition of FGFR1 suppressed these processes. [Oncogene] Full Article

Hypoxia Restrains the Expression of Complement Component 9 in Tumor-Associated Macrophages Promoting Non-Small Cell Lung Cancer Progression

Human NSCLC tumor tissue-conditioned medium (TCM) and adjacent nontumor tissue-conditioned medium (NCM) were used to treat two NSCLC cells LSC1 and LAC1, respectively. Cell growth and foci formation assays were applied to assess the effects of TCM and NCM on cancer cells. [Cell Death Discov] Full Article

A Gender Specific Improved Survival Related to Stromal miR-143 and miR-145 Expression in Non-Small Cell Lung Cancer

The authors investigated the prognostic impact of miR-143 and miR-145 in primary tumors and metastatic lymph nodes in non-small cell lung cancer tissue. [Sci Rep] Full Article

Co-Inhibition of Pol η and ATR Sensitizes Cisplatin-Resistant Non-Small Cell Lung Cancer Cells to Cisplatin by Impeding DNA Damage Repair

Scientists showed that there was no difference in intracellular uptake of cisplatin or the removal of platinum-DNA adducts between a cisplatin-resistant non-small cell lung cancer (NSCLC) cell line and a cisplatin-sensitive NSCLC cell line. [Acta Pharmacol Sin] Abstract

The Lung and Esophagus: Developmental and Regenerative Overlap

Lung and esophageal development and organogenesis involve a complex interplay of signaling pathways and transcriptional factors. Once the lung and esophagus do separate, their epithelial proliferation and differentiation programs share certain common properties that may fuel adaptive responses to injury and subsequent regeneration. [Trends Cell Biol] Abstract

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Phase III IMpower131 Study Showed Tecentriq (Atezolizumab) plus Chemotherapy (Carboplatin and Abraxane) Reduced the Risk of Disease Worsening or Death for People with Advanced Squamous Non-Small Cell Lung Cancer

Roche announced that results from the Phase III IMpower131 study showed Tecentriq^® plus chemotherapy reduced the risk of disease worsening or death by 29 percent compared with chemotherapy alone in the initial treatment of people with advanced squamous non-small cell lung cancer. [Press release from F. Hoffmann-La Roche Ltd discussing research presented at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

Johnson & Johnson and Boston University Announce a New Alliance Focused on Tackling Lung Cancer

Lung cancer is the leading cause of cancer mortality across the globe, claiming more lives than colon, breast and prostate cancers—combined. Johnson & Johnson Innovation and Boston University announced a five-year alliance aimed at fundamentally changing the way lung cancer is detected and treated—with the hope of changing those grim statistics. [Johnson & Johnson Innovation LLC] Press Release

Addario Lung Cancer Medical Institute Collaborates with Washington University on ctDNA Analysis in Early Stage Lung Cancer Study

The Addario Lung Cancer Medical Institute, a patient-founded not-for-profit global research consortium, announced the launch of a new lung cancer study using Inivata’s InVision^® liquid biopsy platform. [Bonnie J. Addario Lung Cancer Foundation] Press Release

FDA Expands Lilly’s ALIMTA^® (Pemetrexed) Label to Include Combination with KEYTRUDA^® (Pembrolizumab) and Carboplatin as First-Line Treatment for Metastatic Nonsquamous Non-Small Cell Lung Cancer, Irrespective of PD-L1 Expression

Eli Lilly and Company announced that the FDA has granted approval for a new indication for ALIMTA^® in combination with carboplatin and KEYTRUDA^® for the initial treatment of patients with metastatic nonsquamous non-small cell lung cancer, irrespective of PD-L1 expression status. [Eli Lilly and Company] Press Release

Bonnie J. Addario Lung Cancer Foundation and Van Auken Private Foundation Announce the 2018 Young Innovators Team Award for Lung Cancer Research

The Bonnie J. Addario Lung Cancer Foundation, in collaboration with the Van Auken Private Foundation, announced the 2018 Young Innovators Team Award to fund and support teams of young investigators conducting innovative research with a potential of delivering meaningful and measurable results in the field of lung cancer. [Bonnie J. Addario Lung Cancer Foundation] Press Release

Aduro Biotech Announces Initiation of Phase Ib Clinical Trial in Non-Small Cell Lung Cancer under Janssen Strategic Partnership for ADU-214 in Combination with Nivolumab

Aduro Biotech, Inc. announced the recent initiation of a Phase Ib study of ADU-214 in combination with nivolumab for the treatment of advanced lung cancer. [Aduro Biotech, Inc.] Press Release

Go for Launch: A Former Astronaut Becomes Spain’s Science Minister

Spain has a ministry of science again—and none other than the first Spanish astronaut is leading it. The new transition government led by socialist Pedro Sánchez announced that Pedro Duque, who visited space twice, will be at the helm of the newly created Ministry for Science, Innovation, and Universities. The announcement was cheered by the Spanish scientific community, which has long suffered from declining budgets and bureaucratic hurdles. [ScienceInsider] Editorial

Scientists Fare Poorly in Super Tuesday Primary Vote

Science-minded candidates seeking seats in the next U.S. Congress took a drubbing from their Democratic opponents in a raft of primary elections across the country. [ScienceInsider] Editorial

Chile, Keen to Become a Knowledge Society, Creates a Ministry of Science

Scientists in Chile have welcomed a decision by Congress to create a science ministry. Many researchers hope that a dedicated ministry will give science more prominence and better-coordinated policies—provided the ministry’s budget matches the government’s ambitions to “bring Chile towards an information and knowledge society,” as Gonzalo Blumel, the country’s minister secretary-general of the presidency, put it in a statement issued after the 31 May vote. [ScienceInsider] Editorial

NEW The American Society for Cell Biology (ASCB) Annual Meeting 2018
December 8-12, 2018
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Chief – Integrative Tumor Epidemiology Branch (National Institutes of Health – National Cancer Institute)

NEW Postdoctoral Position – Immunology/Molecular Biology (National Heart, Lung and Blood Institute)

NEW Postdoctoral Position – Vascular or Lung Biology (Yale University School of Medicine)

NEW Postdoctoral Fellow – Human Lung Stem Cells and Regeneration (MedImmune)

NEW Postdoctoral Fellow – Virology and Respiratory Biology (MedImmune)

NEW Assistant or Associate Professor – Genetic Epidemiology (University of Kentucky)

NEW Postdoctoral Scholarship – Cancer Metabolism (Karolinska Institutet)

Research Technologist – Pulmonary (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Immunology (NYU Langone Health)

PhD Student – Novel Concepts for Therapy of Allergy (Helmholtz Zentrum München)

Senior Research Associate – Lung Biology and Alveolar Epithelial Cells (University of Southern California)

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