Pulmonary Cell News 7.48 December 6, 2018 | |
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TOP STORYAir-liquid interface cultures of primary human bronchial epithelial cells from healthy control subjects, asthma and COPD patients were exposed to laundry detergents and detergent residue after rinse. The cytotoxicity and epithelial barrier function were then evaluated. [J Allergy Clin Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)While, miR-145-5p antagonism rescued effects of TGF-β in bronchial epithelial cells following transfection, an aptamer to block TGF-β signaling rescued cigarette smoke and TGF-β mediated suppression of CF transmembrane conductance regulator (CFTR) biogenesis and function in the absence of any transfection reagent. [Mol Ther] Abstract | Full Article Scientists discovered that nerve injury-induced protein 1 (Ninj1) expression increased in bleomycin (BLM)-treated macrophages and alveolar epithelial cells (AECs). Interestingly, macrophages bound to BLM-treated AECs were activated. However, when Ninj1 expression was suppressed in either of AECs or macrophages, contact-dependent activation of macrophages with AECs was diminished. [Sci Rep] Full Article Serum-Reduced Media Impacts on Cell Viability and Protein Expression in Human Lung Epithelial Cells A549 human lung epithelial cell viability and morphology were adversely affected by growing in Opti-MEM. The cellular protein levels of chloride intracellular channel protein 1, proteasome subunit alpha type 2, and heat shock 70 kDa protein 5 were dysregulated in A549 cells after growing in serum-reduced media. [J Cell Physiol] Full Article LncRNA LCPAT1 Is Involved in DNA Damage Induced by CSE Non-coding RNAs are found to be involved in the DNA damage and repair processes induced by cigarette smoke. Researchers investigated the role of lncRNA LCPAT1 in DNA damage caused by CSE in Beas-2B cells. [Biochem Biophys Res Commun] Abstract LUNG CANCERResearchers showed that ectopic over-expression of ferritin heavy subunit (FHC) induced promoter hypermethylation and the down-regulation of miR-125b that, in turn, enhanced p53 protein expression in non-small cell lung cancer (NSCLC) cell lines. FHC over-expression attenuated survival of NSCLC cells by inducing p53-mediated intrinsic apoptosis that was partially abrogated upon miR-125b re-expression. [Cell Death Dis] Full Article The authors reveal that DUXAP9-206 induced non-small cell lung cancer (NSCLC) cell proliferation and metastasis by directly interacting with Cbl-b, an E3 ubiquitin ligase, and reducing the degradation of epidermal growth factor receptor (EGFR) and thereby augmenting EGFR signaling in NSCLC. [J Cell Mol Med] Full Article An TRIM59-CDK6 Axis Regulates Growth and Metastasis of Lung Cancer Mechanistically, TRIM59 played a key role in promoting lung cancer growth and metastasis through the regulation of the extracellular-signal regulated protein kinase signaling pathway and epithelial-to-mesenchymal transition-markers, as validated by loss-of-function studies. [J Cell Mol Med] Full Article Full length semaphorin 6A (SEMA6A) and various truncations were transfected into lung cancer cells to investigate the role of the different domains of SEMA6A in cell proliferation and survival, apoptosis, and in vivo tumor growth. SEMA6A-induced cell signaling was explored using gene silencing, co-immunoprecipitation, and co-culture assays. [Oncogenesis] Full Article Honokiol Induces Apoptosis of Lung Squamous Cell Carcinoma by Targeting FGF2-FGFR1 Autocrine Loop Scientists found that honokiol induced apoptosis and cell cycle arrest in lung squamous cell carcinoma (SCC) cell lines in a time- and dose-dependent manner. Honokiol also restricted cell migration in lung SCC cell lines. Moreover, the expression of FGF2 and the activation of FGFR1 were both downregulated by honokiol. [Cancer Med] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSSmall Animal Models of Respiratory Viral Infection Related to Asthma To understand underlying mechanisms of viral-induced airways disease; investigators have studied respiratory viral infections in small animals. The authors review animal models of human respiratory viral infection employing mice; rats; guinea pigs; hamsters and ferrets. [Viruses] Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSA ‘rule book’ to guide precision combination immunotherapies and to speed up the development of new lung cancer treatments will be created as part of a collaboration between Cancer Research UK, the Francis Crick Institute and Bristol-Myers Squibb. [Cancer Research UK] Press Release Sanofi, Sema4, Mount Sinai Collaborate on Largest Asthma Study of Its Kind Sema4 and the Mount Sinai Health System announced the launch of a five-year collaborative study with Sanofi designed to provide new insights into the biological mechanisms and other factors implicated in asthma. [Icahn School of Medicine at Mount Sinai] Press Release Genentech announced that the FDA approved Tecentriq®, in combination with Avastin®, paclitaxel and carboplatin, for the initial treatment of people with metastatic non-squamous non-small cell lung cancer with no EGFR or ALK genomic tumor aberrations. [Genentech, Inc.] Press Release AbbVie announced the decision to stop enrollment for the TAHOE trial, a Phase III study evaluating Rovalpituzumab Tesirine (Rova-T) as a second-line therapy for advanced small-cell lung cancer. An Independent Data Monitoring Committee recommended stopping enrollment in TAHOE due to shorter overall survival in the Rova-T arm compared with the topotecan control arm. [AbbVie Inc.] Press Release aTyr Pharma, Inc. announced the initiation of a Phase Ib/IIa study evaluating its lead candidate, ATYR1923, in patients with pulmonary sarcoidosis following acceptance of the company’s investigational new drug application by the FDA. [aTyr Pharma, Inc.] Press Release Aridis Pharmaceuticals, Inc. announced that the Cystic Fibrosis Foundation has more than doubled its research agreement for the clinical development of AR-501 from $2.9 million to up to $7.5 million. Additionally, the FDA cleared AR-501’s Investigational New Drug Application and the company intends to initiate the Phase I/IIa clinical trial next month. [Aridis Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSSci-Hub Blocked in Russia following Ruling by Moscow Court Sci-Hub, the popular pirate site that bypasses paywalls to illicitly host millions of pay-to-read scientific papers, is being blocked in Russia after a court in the country ruled against the site. [The Royal Society of Chemistry] Editorial China Backs Bold Plan to Tear Down Journal Paywalls In a huge boost to the open-access movement, librarians and funders in China have said that they intend to make results of publicly funded research free to read immediately on publication. The move includes a pledge of support for Plan S, a bold initiative launched in September by a group of European funders to ensure that, by 2020, their scientists make papers immediately open. [Nature News] Editorial
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EVENTSNEW AACR Annual Meeting 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Researcher – Lung Cancer Research (University of Cologne) Research Associate – Gene Therapy Lung Research (Imperial College of London) Postdoctoral Position – Pulmonary Fibrosis Research (University of California San Francisco) Staff Scientist/ Tier 2 Canada Research Chair – Lung Research (University of Toronto) Faculty Positions – Cancer-Focused Target & Drug Discovery (University of New Mexico) Postdoctoral Research Fellow – Sepsis & Lung Inflammation Pathogenesis Research (Boston University) Associate Professor – Oncology (University of California, Davis) Postdoctoral Scholar – Cancer Metabolism (The Moffitt Cancer Center) Postdoctoral Position – Lung Cancer Biology (UT Southwestern Medical Center) Postdoctoral Research Scientist – Modeling Infection in Human Lung Organoids (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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