Pulmonary Cell News 8.10 March 21, 2019 | |
| |
TOP STORYIntrinsic Cell-Penetrating Activity Propels Omomyc from Proof of Concept to Viable Anti-MYC Therapy Investigators showed that the purified Omomyc mini-protein itself spontaneously penetrated into non-small cell lung cancer cells and effectively interfered with MYC transcriptional activity therein. [Sci Transl Med] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)A Critical Role for miR-142 in Alveolar Epithelial Lineage Formation in Mouse Lung Development The activation of the glucocorticoid pathway in an in vitro alveolar epithelial lineage differentiation assay led to increased alveolar epithelial type 2 (AT2) marker Sftpc and decreased miR-142 expression. Using miR-142 KO mice, the authors demonstrated an increase in the AT2/AT1 cell number ratio. [Cell Mol Life Sci] Abstract Investigators uncovered that the mitochondrial biogenesis pathway driven by the mTOR/PGC1α/β axis is markedly upregulated in senescent lung epithelial cells. Using two different models, they showed that activation of this pathway associates with other features characteristic of enhanced mitochondrial biogenesis, including elevated number of mitochondrion per cell, increased oxidative phosphorylation and augmented mitochondrial ROS production. [Am J Physiol Lung Cell Mol Physiol] Abstract Pollens Destroy Respiratory Epithelial Cell Anchors and Drive Alphaherpesvirus Infection The authors demonstrated how pollen proteases of Kentucky bluegrass, white birch and hazel selectively destroy integrity and anchorage of columnar respiratory epithelial cells, but not of basal cells, in both ex vivo respiratory mucosal explants and in vitro primary equine respiratory epithelial cells. [Sci Rep] Full Article LUNG CANCERResearchers found evidence of a mechanistic link between receptor tyrosine kinase-like orphan receptor 1 (ROR1)-CAVIN3 interaction and consequential caveolae trafficking, which was found to utilize a binding site distinct from those for ROR1 interactions with caveolin-1 and CAVIN1, with receptor tyrosine kinase-mediated pro-survival signaling towards AKT in early endosomes in lung adenocarcinoma cells. [Oncogene] Abstract C2-ceramide exhibited dose-dependent anticancer effects in H460 and H1299 cells and autophagy induction. Zebrafish-based acridine orange staining confirmed the combined effects in vivo. [Cancers] Full Article | Graphical Abstract Scientists observed that epimagnolin, a natural compound abundantly found in Shin-Yi, suppressed cell proliferation by inhibition of epidermal growth factor-induced G1/S cell-cycle phase transition in JB6 Cl41 cells. Epimagnolin efficiently suppressed cell proliferation and anchorage-independent colony growth of H1650, rather than H460, lung cancer cells with dependency of total and phosphorylated protein levels of mTOR and Akt. [Mol Carcinog] Abstract Scientists evaluated whether DUOX1 silencing in lung cancers may be responsible for altered epidermal growth factor receptor (EGFR) regulation. In contrast to normal epithelial cells, EGF stimulation of lung cancer cell lines that lack DUOX1 promoted EGF-induced EGFR internalization and nuclear localization, associated with induction of EGFR-regulated genes and related tumorigenic outcomes. [Sci Rep] Full Article Researchers found that S100 calcium-binding protein A4 (S100A4) or NDUFS2 silencing inhibited mitochondrial complex I activity, reduced cellular ATP level, decreased invasive capacity in 3D growth, and dramatically decreased metastasis rates as well as tumor growth in vivo. [J Biol Chem] Full Article | Abstract Combination of Hesperetin and Platinum Enhances Anticancer Effect on Lung Adenocarcinoma Hesperetin suppressed lung adenocarcinoma cell proliferation and migration. The combination treatment of hesperetin with platinum suppressed tumor progression more significantly, especially compared with single drug treatment. [Biomed Pharmacother] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
| |
REVIEWSPlatinum-based chemotherapy has long been the first-line treatment of choice for metastatic non-small-cell lung cancer (NSCLC) patients who lack targetable gene mutations. The arrival of checkpoint blockade has led to a vast shift in the treatment landscape of NSCLC. In this review, the authors focus on the molecular rational for the combination therapy and the results of completed clinical studies. [Mol Ther Oncolytics] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
| |
INDUSTRY NEWSA new partnership between LUNGevity Foundation, Pattern.org and the Broad Institute of MIT and Harvard will allow lung cancer patients undergoing a surgical resection or a drainage for pleural effusion to direct their excess cancer tissue and fluid samples towards development of next-generation research models. [LUNGevity Foundation] Press Release Genomics England and Cambridge Cancer Genomics Announce Immunotherapy Partnership Genomics England and Cambridge Cancer Genomics have announced a broad partnership to improve UK-patient access to immune-system modulating cancer drugs, monitor treatment effectiveness over time, and rapidly identify resistance to these drugs. [Cambridge Cancer Genomics] Press Release Resverlogix Corp. announced the advancement of a $2.9 million project led by academic collaborators at Quebec Heart and Lung Institute, Laval University, to research the clinical potential of its lead drug apabetalone as a potential therapy for pulmonary arterial hypertension. [Resverlogix Corp.] Press Release Genentech announced that the FDA has approved Tecentriq®, in combination with carboplatin and etoposide (chemotherapy), for the initial treatment of adults with extensive-stage small cell lung cancer. [Genentech] Press Release US FDA Grants Saracatinib Orphan Drug Designation for Idiopathic Pulmonary Fibrosis The FDA has granted Orphan Drug Designation for saracatinib, a potential new medicine for the treatment of idiopathic pulmonary fibrosis, a type of lung disease that results in scarring of the lungs. [AstraZeneca] Press Release | |
| |
POLICY NEWSEU’s Biggest Research Program Yet Takes Shape The European Union’s three governing institutions — the Parliament, Council and Commission — reached agreement in the small hours of 20 March on the outline of the EU’s next seven-year research-funding program. [Nature News] Editorial Canada Budget Overlooks Basic Research What a difference a year makes. Canada’s 2019 budget, released on March 19th, includes modest increases for Prime Minister Justin Trudeau’s government priorities, including neuroscience and genomics research ― nothing like the historic five-year, Can$4-billion boost for basic science and research unveiled in 2018. [Nature News] Editorial U.S. Researchers Hope Congress Will Dig NSF Out of a $1 Billion Budget Hole For the second time in three years, President Donald Trump has recommended deep cuts to the National Science Foundation (NSF) in Alexandria, Virginia. And scientists are hoping Congress will again come to the agency’s rescue. [ScienceInsider] Editorial
| |
EVENTSNEW Gordon Research Conference: Lung Development, Injury and Repair 2019 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Associate – Gene Therapy for Cystic Fibrosis (Imperial College London) Scientist – Pulmonary (STEMCELL Technologies Inc.) Group Leaders – Cardiopulmonary Research (Max Planck Institute for Heart and Lung Research) Associate Professor – Primary Ciliary Dyskinesia (University of Southampton) Postdoctoral Fellow – Lung Disease (Icahn School of Medicine at Mount Sinai) Assistant/Associate/Full Professor – Lung Cancer (University of Cincinnati College of Medicine) Postdoctoral Position – Respiratory Research (Monell Chemical Senses Center) Associate Professor – Oncology (University of California, Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pulmonary Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|