Pulmonary Cell News Volume 8.27 | Jul 18 2019

TOP STORY

Involvement of Cigarette Smoke-Induced Epithelial Cell Ferroptosis in COPD Pathogenesis

In vivo and in vitro models showed labile iron accumulation and enhanced lipid peroxidation with concomitant non-apoptotic cell death during cigarette smoke exposure, which were negatively regulated by GPx4 activity. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Peripheral Circulating Exosomes-Mediated Delivery of MiR-155 as a Novel Mechanism for Acute Lung Inflammation

In vitro, researchers demonstrated that serum exosomes from acute lung injury mice delivered miR-155 to macrophages, stimulated NF-κB activation and induced the production of TNF-α and IL-6. [Mol Ther] Abstract

Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator

Scientists found that an RNA-guided nuclease-null Cas9 fused with a tripartite activator, VP64-p65-Rta could activate endogenous cystic fibrosis (CF) transmembrane conductance regulator in cultured human nasal epithelial cells from CF patients. [Mol Ther] Abstract | Full Article

STK11 Is Required for the Normal Program of Ciliated Cell Differentiation in Airways

Researchers showed that STK11 was a physiological factor for the normal program of ciliated cell differentiation by phosphorylating MARK3, which directly suppressed ERK1/2 mediated pRB inactivation. [Cell Discov] Full Article

LUNG CANCER

The Genomic Landscape of Epstein-Barr Virus-Associated Pulmonary Lymphoepithelioma-Like Carcinoma

Multi-dimensional comparison unveiled that pulmonary lymphoepithelioma-like carcinomas resembled NPC but were clearly different from other lung cancers, natural killer/T-cell lymphoma or Epstein-Barr virus-related gastric cancer in terms of genetic features. [Nat Commun] Full Article

Inhibition of mTOR Complex 1/p70 S6 Kinase Signaling Elevates PD-L1 Levels in Human Cancer Cells through Enhancing Protein Stabilization Accompanied with Enhanced β-TrCP Degradation

Investigators revealed a previously undiscovered role of mammalian target of rapamycin (mTOR) complex 1/p70 S6 kinase in the negative regulation of programmed death-ligand 1 (PD-L1) on cancer cells and tissues. [Oncogene] Abstract

Autophagosome Accumulation-Mediated ATP Energy Deprivation Induced by Penfluridol Triggers Nonapoptotic Cell Death of Lung Cancer via Activating Unfolded Protein Response

The antitumor activity of penfluridol was determined in vitro in non-small-cell lung cancer cell lines using MTS, plate clonogenic, and transwell migration assays and in vivo in an orthotopic xenograft model. [Cell Death Dis] Full Article

The Inhibition of Chloride Intracellular Channel 1 Enhances Ca²⁺ and Reactive Oxygen Species Signaling in A549 Human Lung Cancer Cells

Depletion of chloride intracellular channel 1 via shRNAs in A549 cells increased DNA double-strand breaks both under control conditions and under treatment with the putative anticancer agent chelerythrine, accompanied by a concomitant increase in the p-JNK level. [Exp Mol Med] Full Article

Acute and Chronic Hypoxia Differentially Predispose Lungs for Metastases

Scientists used primary pulmonary endothelial cells and mouse models with pulmonary endothelium-specific deletion of HIF-1α or HIF-2α, to characterize their roles in vascular integrity, inflammation and metastatic take after acute and chronic hypoxia. [Sci Rep] Full Article

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Impaired Dendritic Cell Functions in Lung Cancer: A Review of Recent Advances and Future Perspectives

The authors summarize the recent advances in understanding on lung tumor-induced immunosuppression in dendritic cells, which affect the initiation and development of T-cell responses. [Cancer Commun] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

Genkyotex Announces FDA Approval of Phase II Investigator-Initiated Trial with GKT831 in IPF

Genkyotex announced FDA has approved the Investigational New Drug application allowing the initiation of a Phase II trial of the company’s lead product candidate, GKT831, in patients with idiopathic pulmonary fibrosis (IPF). [Genkyotex] Press Release

Neon Therapeutics’ Personal Neoantigen Vaccine Study Demonstrates Prolonged Progression-Free Survival in Advanced or Metastatic Melanoma, Non-Small Cell Lung and Bladder Cancers

Neon Therapeutics, Inc. announced top-line results, with at least 12-month median follow-up, from the ongoing, multicenter Phase Ib clinical trial evaluating NEO-PV-01, Neon’s personal neoantigen vaccine candidate, in combination with OPDIVO in patients with advanced or metastatic melanoma, smoking-associated non-small cell lung cancer and bladder cancer. [Neon Therapeutics, Inc.] Press Release

OncBioMune Announces Compelling Pre-Clinical Data for Its CD71-Targeted Chemotherapy, PGT, in Models of Lung, Pancreatic and Ovarian Cancers

OncBioMune Pharmaceuticals, Inc. announced the results of in vitro data for PGT in models of multi-drug resistant lung, pancreatic, and ovarian cancer. [OncBioMune Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Press Release

Exelixis Updates Phase Ib COSMIC-021 Trial of Cabozantinib in Combination With Atezolizumab in Patients With Advanced Solid Tumors

Exelixis, Inc. announced that two original cohorts are being expanded and four new cohorts are being added to the protocol for COSMIC-021, the Phase Ib trial of CABOMETYX^® in combination with atezolizumab in patients with locally advanced or metastatic solid tumors. [Exelixis, Inc. (Business Wire, Inc.)] Press Release

The Plan to Mine the World’s Research Papers

Carl Malamud is on a crusade to liberate information locked up behind paywalls — and his campaigns have scored many victories. Now, the 60-year-old American technologist is turning his sights on a new objective: freeing paywalled scientific literature. And he thinks he has a legal way to do it. [Nature News] Editorial

Virologists Escorted Out of Lab in Canada

Canada’s national police force is investigating “possible policy breaches” after researchers were escorted from a lab at Canada’s National Microbiology Laboratory in Winnipeg, CBC News reported. Prominent virologist Xiangguo Qiu, her colleague and husband Keding Cheng, and an unknown number of her students from China were removed from the lab. [The Scientist] Editorial

NEW Atlanta Lung Cancer Symposium
November 2, 2019
Atlanta, Georgia, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Lung Epithelium (Boston University)

Postdoctoral Positions – Pulmonary Injury (University of Maryland)

Scientist – Pulmonary (STEMCELL Technologies Inc.)

PhD Studentship – Extracellular Vesicles in Pulmonary Fibrosis (Université de Franche-Comté)

Postdoctoral Position – Lung Injury (University of Connecticut)

Postdoctoral Fellowship – Redox Biology of Lung and Breast Cancer (Washington University School of Medicine)

Postdoctoral Fellow – Pluripotent Stem Cell-Derived Human Lung Organoids (Columbia University Irving Medical Center)

Postdoctoral Researcher – Cystic Fibrosis Stem Cell Models (The University of Alabama at Birmingham)

Postdoctoral Researcher – Lung Lineage Development (Hospital for Sick Children)

Assistant Professor – Lung Disease Research (University of McGill)

Postdoctoral Fellowship – RNA in Lung Sepsis and Inflammation (Boston University)

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