Pulmonary Cell News 8.31 August 15, 2019 | |
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TOP STORYInvestigators showed that depletion of the FERM and PDZ domain-containing protein tyrosine phosphatase PTPN3 enhanced lung cancer cell migration/invasion and metastasis by promoting actin filament assembly and focal adhesion dynamics. [Oncogene] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Tiotropium blocked both extracellular regulated kinase phosphorylation and calcium mobilization, consistent with the hypothesis that the drug prevents microparticle generation through inhibition of these critical pathways. [Sci Rep] Full Article Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction Researchers defined the mechanism by which bacterial factors modulate host lung epithelial cell mitochondrial function and investigated novel therapies that ameliorated this effect. [Sci Rep] Full Article LUNG CANCERThe Hippo Pathway Modulates Resistance to BET Proteins Inhibitors in Lung Cancer Cells To uncover the mechanisms of resistance to inhibitors of BET proteins (BETi), scientists performed a genome-scale CRISPR/Cas9 screening in lung cancer cells. They identified three Hippo pathway genes, LATS2, TAOK1, and NF2, as key determinants for sensitivity to BETi. [Oncogene] Abstract Transferrin-adorned thymoquinone nanoparticles successfully coupled two distinct miRNA pathways to potentiate the apoptotic death cascade in very lethal non-small cell lung carcinoma cells and also restricted the migration of these cells without imparting any significant toxicity, which occurs in widely used chemotherapeutic combinations. [Biomater Sci] Abstract Exosomal PD-L1 Promotes Tumor Growth through Immune Escape in Non-Small Cell Lung Cancer Investigators showed that exosomes derived from lung cancer cells expressed programmed cell death ligand-1 (PD-L1) and played a role in immune escape by reducing T cell activity and promoting tumor growth. [Exp Mol Med] Full Article Researchers showed that knockdown of NONMMUT015812 by shRNAs decreased proliferation and migration abilities of primary murine lung adenocarcinoma cells cells. Among those aberrantly expressed lncRNAs in the mouse lung adenocarcinoma, NONMMUT015812 was a potential oncogene. [J Cell Mol Med] Full Article Scientists describe a novel support, called CytoMatrix, for the characterization of limited amounts of cancer cells isolated from malignant pleural effusions of patients with non-small-cell lung cancer. They showed that this synthetic matrix allowed an easy and fast characterization of several epithelial cellular markers. [J Cell Physiol] Full Article Suppression of syncytin 1 inhibited the migration and invasion, as well as the expressions of epithelial-mesenchymal transition (EMT) makers, N-cadherin, β-catenin, and vimentin, indicating that syncytin 1 knockdown inhibited the metastasis via reversing the EMT process in A549 cells. [Cancer Med] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSCo-Occurring Genomic Alterations in Non-Small-Cell Lung Cancer Biology and Therapy Researchers discuss the impact of co-mutations on the pathogenesis, biology, microenvironmental interactions and therapeutic vulnerabilities of non-small-cell lung cancer and assess the challenges and opportunities that co-mutations present for personalized anticancer therapy, as well as the expanding field of precision immunotherapy. [Nat Rev Cancer] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSCStone Pharmaceuticals announced the dosing of the first patient in China for the Phase I registrational study of BLU-667, which was discovered by the company’s partner Blueprint Medicines. This clinical trial is a part of the ongoing, global Phase I ARROW trial that is designed to evaluate the overall response rate, duration of response, pharmacokinetics, pharmacodynamics and safety of BLU-667 in patients with RET-altered non-small cell lung cancer, medullary thyroid cancer and other advanced solid tumors. [CStone Pharmaceuticals (PR Newswire Association LLC.)] Press Release Vaccinex, Inc. announced that full enrollment has been achieved in the ongoing CLASSICAL-Lung Phase Ib/II clinical trial evaluating the company’s lead clinical candidate, pepinemab, in combination with anti-PD-L1 checkpoint inhibitor, BAVENCIO®, for the treatment of advanced non-small cell lung cancer. [Vaccinex, Inc.] Press Release | |
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POLICY NEWSUC Faculty Members Quit Cell Press Editorial Boards over Impasse with Publisher Some of the University of California’s (UC’s) most prominent scientists have announced they will resign from editorial boards of Cell Press to protest the continuing impasse between its owner, publishing giant Elsevier, and UC over subscription costs and open access to articles. [ScienceInsider] Editorial Academia to FBI on Monitoring Chinese Scientists: “Tread Carefully” Nearly two dozen higher education groups warn the government to be cautious when advising US research universities to keep an eye on students and faculty with ties to certain Chinese institutions. [The Scientist] Editorial
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EVENTSNEW European Cancer (ECCO) Summit 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Lung-on-Chip Modeling (University of Bern) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Scientist – Pulmonary (STEMCELL Technologies Inc.) Postdoctoral Research Fellow – Lung Cancer (University Hospital of Cologne) Postdoctoral Research Fellow – Lung Cancer Immunology (Memorial Sloan Kettering Cancer Center) Assistant/Associate Professor – Respiratory Tract Infections (Hannover Medical School) Postdoctoral Fellowship – Lung Epithelium (Boston University) Postdoctoral Positions – Pulmonary Injury (University of Maryland) PhD Studentship – Extracellular Vesicles in Pulmonary Fibrosis (Université de Franche-Comté) Postdoctoral Position – Lung Injury (University of Connecticut) Postdoctoral Researcher – Lung Lineage Development (Hospital for Sick Children) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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