Pulmonary Cell News 8.35 September 12, 2019 | |
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TOP STORYOncogenic KRAS Sensitizes Lung Adenocarcinoma to GSK-J4-Induced Metabolic and Oxidative Stress Lung adenocarcinoma (LuAC) cell lines harboring KRAS mutations showed hypersensitivity to the histone H3K27 demethylase inhibitor GSK-J4. GSK-J4 treatment of KRAS mutant-containing LuAC downregulated cell cycle progression genes with increased H3K27me3. [Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that transmembrane 4 L six family member 5 (TM4SF5) in lung epithelial cells induced the alternatively spliced CD44v8-10 variant via an inverse ZEB2/epithelial splicing regulatory proteins linkage. [Cell Death Dis] Full Article In in vitro and in vivo studies, the levels of fibrosis indicators including α-SMA, vimentin, collagen-I and hydroxyproline in carbon black treatment groups statistically increased in dose- or time- dependent manners compared with the control. [Nanotoxicology] Abstract The authors showed that forced miR-206 expression restored gefitinib sensitivity in IL6-induced gefitinib‐resistant epidermal growth factor receptor (EGFR)-mutant lung cancer cells by inhibiting IL6/JAK1/STAT3 pathway. [J Cell Mol Med] Full Article Vitamin D Modulates the Response of Bronchial Epithelial Cells Exposed to Cigarette Smoke Extract Researchers examined the effects of vitamin D on a human bronchial epithelial cell line and on air-liquid culture of primary bronchial epithelial cells of COPD patients and controls exposed for 24 hours to cigarette smoke extract. [Nutrients] Full Article LUNG CANCERInvestigators report that fascin, an actin-bundling protein, promoted lung cancer metastatic colonization by augmenting metabolic stress resistance and mitochondrial oxidative phosphorylation. [Cell Rep] Full Article | Graphical Abstract Patient-derived tumorspheres showed self-renewal and unlimited exponential growth potentials, resistance against chemotherapeutic agents, invasion and differentiation capacities in vitro, and superior tumorigenic potential in vivo. [Cell Death Dis] Full Article Antagonizing integrin beta3 increased the TKI sensitivity and delayed the occurrence of TKI resistance in vitro and in vivo, as well as suppressed proliferation, anoikis resistance and EMT phenotype in lung cancer cells. [Mol Cancer Ther] Abstract Reciprocal Regulatory Mechanism between miR-214-3p and FGFR1 in FGFR1-Amplified Lung Cancer miR-214-3p was sharply decreased and showed a significantly negative correlation with fibroblast growth factor receptor 1 (FGFR1) in lung cancer patients. Luciferase reporter assay confirmed that miR-214-3p could downregulate FGFR1 by directly targeting 3′-untranslated region. [Oncogenesis] Full Article Researchers showed that treatment with ouabain caused simultaneous activation of AMPK and Src signaling pathways in human lung cancer A549 cells and human breast cancer MCF7 cells. [Acta Pharmacol Sin] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSAdvanced In Vitro Lung-on-Chip Platforms for Inhalation Assays: From Prospect to Pipeline With rapid advances in micro-fabrication processes and the availability of biologically-relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for more realistic inhalation assays in pharmaceutical research, and thereby an opportunity to depart from traditional in vitro lung assays. [Eur J Pharm Biopharm] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSRoche announced positive data from the Phase III IMpower110 study evaluating Tecentriq® as a first-line monotherapy compared with cisplatin or carboplatin and pemetrexed or gemcitabine in advanced non-squamous and squamous non-small cell lung cancer without ALK or EGFR mutations. [F. Hoffmann-La Roche Ltd] Press Release Armata Pharmaceuticals, Inc. announced that the company has developed a new synthetic phage candidate targeting the pathogen Pseudomonas aeruginosa to treat serious respiratory infections, with an emphasis on CF patients. [Armata Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSClubby and ‘Disturbing’ Citation Behavior by Researchers in Italy Has Surged The rate at which scientists in Italy cite themselves and their compatriots is rising faster than in ten other developed countries, according to a new study. The surge in Italy’s clubby citation behavior is likely the result of a 2010 law requiring productivity standards for academic recruitment or promotion, the study authors say. [ScienceInsider] Editorial EU Research Commissioner Named, but Lacks ‘Research’ in Her Title Mariya Gabriel, a conservative politician from Bulgaria, is slated to become the next European research chief- although her job title, unlike that of her predecessors, doesn’t include the words “research” or “science”. [ScienceInsider] Editorial Frontrunner to Lead FDA, Dogged by Controversies, Has Developed Knack for Confronting Them Before he interviewed with President Trump to become FDA commissioner, Dr. Stephen Hahn had only been here once in a formal capacity: to apologize to Congress. [STAT News] Editorial
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EVENTSNEW Gene Regulation: From Mechanisms to Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Positions – Sepsis and Pulmonary Injury (University of Maryland) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Scientist – Pulmonary (STEMCELL Technologies Inc.) Postdoctoral Position – Small Cell Lung Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Position – Lung Inflammation (The Boston University Pulmonary Center) Postdoctoral Scientist – Small Cell Lung Cancer (Cancer Research UK Manchester Institute) Associate Director – Pulmonary Biology (Translate Bio, Inc.) Postdoctoral Research Fellow – Lung Cancer (University Hospital of Cologne) Postdoctoral Research Fellow – Lung Cancer Immunology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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