Pulmonary Cell News Volume 8.44 | Nov 14 2019

TOP STORY

An Inhalable Nanoparticulate Sting Agonist Synergizes with Radiotherapy to Confer Long-Term Control of Lung Metastases

Inhalation of phosphatidylserine coated liposome loaded with STING agonist cyclic guanosine monophosphate-adenosine monophosphate (NP-cGAMP) in mouse models of lung metastases enabled rapid distribution of NP-cGAMP to both lungs and subsequent uptake by antigen presenting cells without causing immunopathology. [Nat Commun] Full Article

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Bioinspired In Vitro Lung Airway Model for Inflammatory Analysis via Hydrophobic Nanochannel Membrane with Joint Three-Phase Interface

Scientists developed a bioinspired nanoporous membrane with three-phase interface as gas exposure model that mimicked the airway working mechanism, gas molecules contacting with alveolar cell directly, enabling high cell viability and sensitive inflammatory response analysis. [Anal Chem] Abstract

LKB1/p53/TIGAR/Autophagy-Dependent VEGF Expression Contributes to PM2.5-Induced Pulmonary Inflammatory Responses

Researchers revealed that TIGAR was a transcriptional target of p53 to trigger autophagy and VEGF upregulation in Beas-2B cells after PM2.5 exposure. Furthermore, LKB1, but not ATR and CHK1, played a critical role in mediating p53/TIGAR/autophagy/VEGF pathway activation also by linking to Src/STAT3 signaling cascade. [Sci Rep] Full Article

Equine Bronchial Fibroblasts Enhance Proliferation and Differentiation of Primary Equine Bronchial Epithelial Cells Co-Cultured under Air-Liquid Interface

After about 15–20 days of co-culture at air-liquid interface, P0 and P1 equine bronchial epithelial cell monolayers showed pseudo-stratified architecture, presence of ciliated cells, typically honeycomb-like pattern of tight junction protein 1 expression, and intact selective barrier functions. [PLoS One] Full Article

LUNG CANCER

ZEB1/NuRD Complex Suppresses TBC1D2b to Stimulate E-Cadherin Internalization and Promote Metastasis in Lung Cancer

Scientists applied two independent screens, BioID and an Epigenome shRNA dropout screen, to define ZEB1 interactors that are critical to metastatic non-small cell lung cancer. They identified the NuRD complex as a ZEB1 co-repressor and the Rab22 GTPase-activating protein TBC1D2b as a ZEB1/NuRD complex target. [Nat Commun] Full Article

Circular RNA cESRP1 Sensitises Small Cell Lung Cancer Cells to Chemotherapy by Sponging miR-93-5p to Inhibit TGF-β Signaling

The authors observed that circular RNA epithelial splicing regulatory protein-1 (cESRP1) expression was significantly downregulated in the chemoresistant cells compared with the parental chemosensitive cells. cESRP1 enhanced drug sensitivity by repressing miR-93-5p in small cell lung cancer. [Cell Death Differ] Full Article

B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells

RNA-seq and ATAC-seq data disentangled transcriptional and genome accessibility variability of 3D vs. 2D cultures in NCI-H460 cells. The examination of genomic landscape of genes upregulated in 3D vs. 2D cultures led to the identification of 2D cultures led to the identification of beta-1,4-galactosyltranferase 1 (B4GALT1) as the top candidate. [J Clin Med] Full Article

LncRNA DLEU2 Accelerates the Tumorigenesis and Invasion of Non-Small Cell Lung Cancer by Sponging miR-30a-5p

Silencing of long non-coding RNA (lncRNA) deleted in lymphocytic leukemia 2 (DLEU2) repressed the tumorigenesis and invasive potential of non-small cell lung cancer, whereas re-expression of lncRNA DLEU2 showed the opposite effects. [J Cell Mol Med] Abstract

miR-146b Reverses Epithelial-Mesenchymal Transition via Targeting PTP1B in Cisplatin-Resistance Human Lung Adenocarcinoma Cells

Compared with the control group, H1299/DDP and A549/DDP cells showed the enhanced epithelial-mesenchymal transformation phenotypes, invasion and migration ability. Besides, miR-146b was lowly expressed in H1299/DDP and A549/DDP cells. [J Cell Biochem] Abstract

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The Roles of Exosomal miRNAs and lncRNAs in Lung Diseases

The authors summarized recent knowledge about the roles of exosomal miRNAs and long noncoding RNAs (lncRNAs) in lung diseases, which has shed light on the discovery of novel diagnostic methods and treatments for these disorders. [Signal Transduct Target Ther] Full Article

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Akoya Expands Spatial Biology Portfolio with Optimized PD-1/PD-L1 Panels for Melanoma and Lung Cancer

Akoya Biosciences, Inc. announced that it has launched two new multiplex immunofluorescence kits, expanding its portfolio of solutions for profiling immuno-oncology biomarkers in the tumor microenvironment. These kits focus on PD-1 immune checkpoint blockade in lung cancer and in melanoma. [Akoya Biosciences, Inc.] Press Release

Turning Point Therapeutics Initiates Phase I/II Clinical Study of TPX-0046, a Novel RET/SRC Inhibitor

Turning Point Therapeutics, Inc. announced initiation of a Phase I/II clinical study of its drug candidate TPX-0046 in patients with advanced solid tumors harboring RET genetic alterations. [Turning Point Therapeutics, Inc.] Press Release

Vitamin E Acetate Tied to Vaping Illnesses: CDC

Health officials at the Centers for Disease Control and Prevention have identified vitamin E acetate as a possible culprit in the recent string of vaping-related illnesses and deaths, according to a news briefing. [The Scientist] Editorial

Italy to Launch National Agency for Research

Just two months after Italy underwent a crisis of government and established an alliance between two leading political parties, the left-of-center Democratic Party and the anti-establishment Five Star Movement, the country has announced plans to start a National Agency for Research to help oversee the distribution of federal funds. [The Scientist] Editorial

More South Korean Academics Caught Naming Kids as Co-Authors

The number of South Korean academics accused of naming children as co-authors on research manuscripts — even though the children did not contribute to the research — continues to grow. [Nature News] Editorial

What the Protests and Violence in Chile Mean for Science

As universities shut down, researchers are demonstrating — and meeting with lawmakers to figure out if science can help solve socio-economic inequality. [Nature News] Editorial

NEW Linking Cells, the Cytoskeleton and the Nucleus in Mechanobiology, Aging and Disease
June 7-12, 2020
West Dover, Vermont, United States

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NEW PhD Student – Organ-on-Chip (Helmholtz Zentrum München)

Postdoctoral Fellow – Pulmonary Research (Universitätsklinikum Erlangen)

Postdoctoral Fellow – Lung Cancer Epigenomics (Icahn School of Medicine at Mount Sinai)

Postdoctoral Research Fellow – Small Cell Lung Cancer (University Hospital of Cologne)

PhD Studentship – Small Cell Lung Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Research Fellow – Lung Development and Disease (Center for Regenerative Medicine)

Research Fellow – Lung Cancer (Dana-Farber Cancer Institute)

Faculty Position – Pulmonary and Critical Care Medicine (Mayo Clinic Comprehensive Cancer Center)

Research Scientist – Fibrosis (Gilead Sciences, Inc.)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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