Pulmonary Cell News Volume 8.46 | Nov 28 2019

TOP STORY

Causative Role of PDLIM2 Epigenetic Repression in Lung Cancer and Therapeutic Resistance

While PDLIM2 was epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its global or lung epithelial-specific deletion in mice caused increased lung cancer development, chemoresistance, and complete resistance to anti-PD-1 and epigenetic drugs. [Nat Commun] Full Article

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Microarray-Assisted Size-Effect Study of Amorphous Silica Nanoparticles on Human Bronchial Epithelial Cells

Microarray analysis was performed to investigate the genome-wide transcriptional alteration induced by different sizes of silica nanoparticles in human primary bronchial epithelial cells. [Nanoscale] Abstract

Comparative Therapeutic Potential of ALX-0171 and Palivizumab against RSV Clinical Isolate Infection of Well-Differentiated Primary Pediatric Bronchial Epithelial Cell Cultures

To characterize the therapeutic potential of ALX-0171, the authors exploited a well-differentiated primary pediatric bronchial epithelial cell/respiratory syncytial virus (RSV) infection model, which replicated several hallmarks of RSV disease in vivo. [Antimicrob Agents Chemother] Abstract

Nanomolar-Potency ‘Co-Potentiator’ Therapy for Cystic Fibrosis Caused by a Defined Subset of Minimal Function CFTR Mutants

To investigate the range of cystic fibrosis transmembrane conductance regulator (CFTR) mutations benefitted by co-potentiators, 14 CF-associated CFTR mutations were studied in transfected cell models. [Sci Rep] Full Article

Vasorin/ATIA Promotes Cigarette Smoke-Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis

Vasorin expression was examined in human lung cancer tissues with immunohistochemistry and database analysis. Genetic and pharmacological approaches were used to manipulate protein expression and autophagy activity in human bronchial epithelial cells. [Transl Oncol] Full Article

Hydrogen Sulfide Inhibits Cigarette Smoke-Induced Inflammation and Injury in Alveolar Epithelial Cells by Suppressing PHD2/HIF-1α/MAPK Signaling Pathway

Sodium hydrosulfide significantly increased the expressions of tight junction proteins, and reduced apoptosis and secretion of pro-inflammatory cytokines in cigarette smoke (CS)-exposed mouse lungs and CS extract-incubated A549 cells. [Int Immunopharmacol] Abstract

LUNG CANCER

Proteasome-Dependent Degradation of Smad7 Is Critical for Lung Cancer Metastasis

Activated TGFβ signaling in REGγ-positive lung cancer cells led to diminished expression of E-cadherin, a biomarker of epithelial-mesenchymal transitions, and elevated mesenchymal markers compared with REGγ-deficient lung cancer cells. [Cell Death Differ] Abstract

CircRNA-ENO1 Promoted Glycolysis and Tumor Progression in Lung Adenocarcinoma through Upregulating Its Host Gene ENO1

Circ-ENO1 and its host gene enolase 1 (ENO1) were identified to be upregulated in LUAD cells. Functionally, silencing circ-ENO1 retarded glycolysis, inhibited proliferation, migration and EMT, induced apoptosis. [Cell Death Dis] Full Article

The Balance between NRF2/GSH Antioxidant Mediated Pathway and DNA Repair Modulates Cisplatin Resistance in Lung Cancer Cells

Scientists used established normal and malignant lung cell lines displaying different sensitivity towards cisplatin treatment. They observed a negative correlation between cell viability and DNA damage induction upon cisplatin treatment. [Sci Rep] Full Article

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Cell-Specific DNA Methylation Signatures in Asthma

The authors compare alterations in DNA methylation from different cells of the immune system and of the respiratory tract. The cell types in which data are obtained influences the global status of alteration of DNA methylation in asthmatic individuals compared to control. [Genes (Basel)] Full Article

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OSE Immunotherapeutics and HalioDx Collaborate to Perform Immune Biomarker Exploratory Work during Atalante 1 Phase III Clinical Trial of Tedopi^® in Non-Small Cell Lung Cancer

OSE Immunotherapeutics and HalioDx announced a collaboration to conduct a translational investigation of immune biomarkers as part of the ongoing Phase III clinical trial of neoepitope combination Tedopi^® in non-small cell lung cancer patients. [OSE Immunotherapeutics] Press Release

CytoDyn’s Lead Product Candidate Leronlimab (PRO 140) Inhibits Colon Carcinoma Metastases to Liver and Lung in Preclinical Studies

CytoDyn Inc. announced that leronlimab inhibited a human colon carcinoma cell line, SW480 cells, metastases to liver and lung in a well-accepted mouse model. [CytoDyn Inc.] Press Release

PhD Students in China Report Misery and Hope

In a Nature survey, only 55% of the Chinese students who responded to the survey said that they were at least partially satisfied with their PhD experience. For the 5,630 respondents outside China, the satisfaction rate was 72%. [Nature News] Editorial

Chinese Ministry Investigates Duplications in Papers by University President

The Chinese education ministry is investigating scientific articles authored by high-profile immunologist and university president Cao Xuetao, following suggestions that dozens of papers contain potentially problematic images. Four journals also say they are examining papers from Cao. [Nature News] Editorial

Stark Party Differences in ‘Brexit Election’ Could Shape Future of UK Science

When representatives of each party took to a stage last week at the Royal Society in London, they all promised increased funding and easier immigration for scientists. But Brexit loomed over the discussion, says Sarah Main, director of the Campaign for Science and Engineering, an advocacy group in London. [ScienceInsider] Editorial

NEW 6^th AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic
January 11-14, 2020
San Diego, California, United States

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NEW Postdoctoral Fellow – Small Cell Lung Cancer (University Hospital of Cologne)

NEW PhD Student Positions – Influenza Research (University Hospital of Muenster)

NEW Postdoctoral Associate – Inflammation (University of Pittsburgh)

PhD Student – Organ-on-Chip (Helmholtz Zentrum München)

Postdoctoral Fellow – Pulmonary Research (Universitätsklinikum Erlangen)

Postdoctoral Fellow – Lung Cancer Epigenomics (Icahn School of Medicine at Mount Sinai)

Postdoctoral Research Fellow – Small Cell Lung Cancer (University Hospital of Cologne)

PhD Studentship – Small Cell Lung Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Research Fellow – Lung Development and Disease (Center for Regenerative Medicine)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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