Pulmonary Cell News 9.05 February 13, 2020 | |
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TOP STORYMechanical Regulation of Glycolysis via Cytoskeleton Architecture Scientists report that the transfer of human bronchial epithelial cells from stiff to soft substrates caused a downregulation of glycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells Researchers reversed microRNA-mediated inhibition of CFTR using CFTR-specific target site blockers and developed a drug-device combination inhalation therapy for cystic fibrosis (CF). Lead microRNA expression was quantified in a series of human CF and non-CF samples and in vitro models. [Mol Ther] Abstract The authors compared the cytotoxicity and genotoxicity of multi-walled carbon nanotubes (MWCNT)-7 and crocidolite using A549 cells grown in a conventional monoculture or in co-culture with THP-1 macrophages. [Nanotoxicology] Abstract Investigators demonstrated that lipopolysaccharides promoted collagen synthesis in the lung fibroblasts through aerobic glycolysis via the activation of the PI3K-Akt-mTOR/PFKFB3 pathway. [Lab Invest] Abstract LUNG CANCERRegenerative Lineages and Immune-Mediated Pruning in Lung Cancer Metastasis The authors showed that human primary lung adenocarcinomas were characterized by the emergence of regenerative cell types, typically seen in response to lung injury, and by striking infidelity among transcription factors specifying most alveolar and bronchial epithelial lineages. [Nat Med] Abstract Up-regulated miR-196b-5p promoted lung cancer cell migration, proliferation, and cell cycle through directly targeting the tumor suppressors, GATA6 and TSPAN12. [Proc Natl Acad Sci USA] Abstract The ACSL3-LPIAT1 Signaling Drives Prostaglandin Synthesis in Non-Small Cell Lung Cancer By using lung cancer cell lines and clinically relevant KrasG12D-driven mouse models, the authors showed that the long-chain acyl-CoA synthetase (ACSL3) channels arachidonic acid into phosphatidylinositols. [Oncogene] Full Article Functional assays showed that inhibition of HOXB-AS3 was able to repress A549 and H1975 cell proliferation, cell colony formation ability and triggered cell apoptosis. [J Cell Physiol] Abstract Investigators identified miR-212-5p as a negative post-transcriptional modulator of Id3. Id3 was lowly expressed and miR-212-5p was highly expressed in non-small-cell lung cancer tissues and cells. [J Cell Physiol] Abstract Association of Divergent Carcinoembryonic Antigen Patterns and Lung Cancer Progression Cell line experiments revealed that carcinoembryonic antigen expression (CEA) and cancer dissemination can be affected by EGFR-tyrosine kinase inhibitor selection. EGFR-mutant patients, exhibiting high CEA at initial diagnosis and low CEA disease progression, showed a potential toward displaying new metastasis. [Sci Rep] Full Article Cancer stem cells were obtained from tumor spheres of H1299 human lung cancer cells. Researchers studied low stiffness, a unique biophysical property of cancer cells, in cancer stem cellsand parental H1299. [Sci Rep] Full Article Identification of Nagilactone E as a Protein Synthesis Inhibitor with Anticancer Activity Researchers found that nagilactone E administration significantly suppressed the tumor growth without obvious adverse effects. RNA sequencing analysis was performed to study the mechanisms of nagilactone E. [Acta Pharmacol Sin] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSImmunotherapeutic Approaches for Small-Cell Lung Cancer The authors describe the available data on clinical efficacy, the emerging evidence regarding biomarkers and ongoing clinical trials using immune-checkpoint inhibitors and other immunotherapies in patients with small-cell lung cancer. [Nat Rev Clin Oncol] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSAduro Biotech, Inc. announced that the company earned a $10.0 million development milestone payment under its worldwide licensing agreement with Merck for the initiation of a Phase II clinical trial of MK-5890, an anti-CD27 agonist, in non-small cell lung cancer. [Aduro Biotech, Inc.] Press Release Novartis, Inc. announced that the FDA accepted and granted Priority Review to capmatinib’s New Drug Application. Capmatinib is a MET inhibitor being evaluated as a treatment for first-line and previously treated patients with locally advanced or metastatic MET exon 14 skipping mutated non-small cell lung cancer. [Novartis, Inc.] Press Release vTv Therapeutics Inc. announced positive results from part two of the Phase II Simplici-T1 trial assessing TTP399 as an oral adjunctive therapy to insulin in adults with type 1 diabetes. [vTv Therapeutics Inc.] Press Release | |
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POLICY NEWSPopular Preprint Servers Face Closure Because of Money Troubles The rise of preprint repositories has helped scientists worldwide to share results and get feedback quickly. But several platforms that serve researchers in emerging economies are struggling to raise money to stay afloat. Repositories like INA-Rxiv and IndiaRxiv boost regional science, but finding cash to run them is proving difficult. [Nature News] Editorial FDA Now Allows Certain Lab Animals to Be Retired and Adopted The US Food and Drug Administration will now permit certain animals used in experiments to retire and be adopted rather than face euthanasia, according to internal documents reviewed by The Hill. Although the policy changed in November, there have not been any public statements from the agency. [The Scientist] Editorial
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EVENTSNEW Asthma: Making New Discoveries into Better Therapies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Cancer Metabolism (The Ohio State University) Postdoctoral Training Fellow – Stem Cells in Tuberculosis (The Francis Crick Institute) Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center) Postdoctoral Fellowship – Stem Cell Niche in Lung Fibrosis (University of California) Postdoctoral Scholarship – Cancer Drug Discovery (Karolinska Institutet) Postdoctoral Position – Bronchial Epithelial Cell Analysis (University Medical Center Groningen) Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology) Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute) Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital) Postdoctoral Research Scientist – Cancer Research (The Beatson Institute for Cancer Research) Postdoctoral Fellow – Lung Cancer (Weill Cornell Medicine) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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