Pulmonary Cell News Volume 9.07 | Feb 27 2020

TOP STORY

Crosstalk with Lung Epithelial Cells Regulates Sfrp2-Mediated Latency in Breast Cancer Dissemination

Scientists revealed how the behavior of indolent breast cancer cells in the lung was determined by their interactions with alveolar epithelial cells, in particular alveolar type 1 cells. [Nat Cell Biol] Abstract

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rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental BPD

Direct effects of rhIGF-1/BP-3 on fetal lung endothelial cell proliferation and tube formation and alveolar type 2 cell proliferation were studied by standard methods in vitro. [Am J Respir Crit Care Med] Abstract

Looping of Upstream cis-Regulatory Elements Is Required for CFTR Expression in Human Airway Epithelial Cells

Investigators determined how two extragenic cis-regulatory elements that were prominent in epithelial cells in the lung, regulate expression of the gene. [Nucleic Acids Res] Abstract

Long-Lived Regulatory T Cells Generated during Severe Bronchiolitis in Infancy Influence Later Progression to Asthma

Using cultured mouse airway epithelial cells, researchers identified that healthy regulatory T cells (Tregs) suppressed allergen-induced high-mobility group box 1 translocation whereas this ability was markedly impaired in aberrant Tregs. [Mucosal Immunol] Abstract

LUNG CANCER

Stromal Hedgehog Pathway Activation by IHH Suppresses Lung Adenocarcinoma Growth and Metastasis by Limiting Reactive Oxygen Species

The authors demonstrated that the canonical Hedgehog (Hh) signaling pathway was activated in lung stroma by (Hh) ligands secreted from transformed lung epithelia. [Oncogene] Full Article

MiR-629-5p Promotes the Invasion of Lung Adenocarcinoma via Increasing Both Tumor Cell Invasion and Endothelial Cell Permeability

In tumor cells, miR-629-5p enhanced motility and invasiveness of tumor cells by directly targeting PPWD1, which clinically related to tumor invasion in lung adenocarcinoma specimens. [Oncogene] Abstract

Deguelin Suppresses Non-Small Cell Lung Cancer by Inhibiting EGFR Signaling and Promoting GSK3β/FBW7-Mediated Mcl-1 Destabilization

By suppression of epidermal growth factor receptor (EGFR) signaling, deguelin inhibited anchorage-dependent, and independent growth of non-small cell lung cancer cell lines, and significantly delayed tumorigenesis in vivo. [Cell Death Dis] Full Article

The Circular RNA NT5E Promotes Non-Small Cell Lung Cancer Cell Growth via Sponging microRNA-134

Scientists showed that circular RNA ecto-5’-nucleotidase levels were significantly elevated in human non-small cell lung cancer tissues and cells, correlating with downregulation of its potential targets, miR-134, miR-422a and miR-338. [Aging (Albany NY)] Full Article

Long Non-Coding RNA ATB Promotes Human Non-Small Cell Lung Cancer Proliferation and Metastasis by Suppressing miR-141-3p

LncRNA-ATB was significantly up-regulated in non-small cell lung cancer tissues and cell lines, and high lncRNA-ATB expression indicated poor prognosis. [PLoS One] Full Article

TRIAP1 Knockdown Sensitizes Non-Small Cell Lung Cancer to Ionizing Radiation by Disrupting Redox Homeostasis

Investigators irradiated human non-small cell lung cancer cell lines, while knocking down TP53-regulated inhibitor of apoptosis 1 (TRIAP1), to determine whether a disrupted redox homeostasis could attenuate radioresistance. [Thorac Cancer] Full Article

Combination of Chemotherapy and PD-1 Blockade Induces T Cell Responses to Tumor Non-Mutated Neoantigens

Researchers developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer cells that had been induced to apoptosis by cisplatin treatment in vitro. [Commun Biol] Full Article

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Noncanonical Wnt Planar Cell Polarity Signaling in Lung Development and Disease

Planar cell polarity dysfunction has been linked to a variety of chronic lung diseases such as cystic fibrosis, COPD, and idiopathic pulmonary arterial hypertension, stemming chiefly from the breakdown of proper tissue structure and function and aberrant cell migration during regenerative wound healing. [Biochem Soc Trans] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

Takeda Announces US FDA Grants Priority Review for Supplemental New Drug Application for ALUNBRIG^® (Brigatinib) as a First-Line Treatment for ALK⁺ Metastatic Non-Small Cell Lung Cancer

Takeda Pharmaceutical Company Limited announced that the FDA has granted priority review for the company’s supplemental New Drug Application to expand the use of ALUNBRIG^® as a first-line treatment for patients with anaplastic lymphoma kinase-positive metastatic non-small cell lung cancer as detected by an FDA-approved test. [Takeda Pharmaceutical Company Limited] Press Release

Translate Bio Receives FDA Fast Track Designation for MRT5005 for the Treatment of Cystic Fibrosis

Translate Bio, Inc. announced that the FDA has granted Fast Track designation for MRT5005 for the treatment of cystic fibrosis (CF). MRT5005, the first mRNA therapeutic with delivery to the lung, is designed to address the underlying cause of CF, regardless of genetic mutation. [Translate Bio, Inc.] Press Release

Federal Judge Rules Clinical Trial Sponsors Must Publish a Decade’s Worth of Missing Data

For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a ten year gap in data that now must be made publicly available. [STAT News] Editorial

Contract Offers Unprecedented Look at Google Deal to Obtain Patient Data from the University of California

It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News] Editorial

NEW American Association for Cancer Research (AACR) Annual Meeting 2020
April 24-29, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Research Associate – Lung Tumors (University of Cambridge)

Research Associate and Lab Manager – In Vitro Cancer Models (Flanders Institute for Biotechnology)

Postdoctoral Scholar – Cancer Metabolism (The Ohio State University)

Postdoctoral Training Fellow – Stem Cells in Tuberculosis (The Francis Crick Institute)

Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center)

Postdoctoral Fellowship – Stem Cell Niche in Lung Fibrosis (University of California)

Postdoctoral Fellowship – Airway Disease Immunology (La Jolla Institute for Immunology)

Multiple Investigator Positions – Cancer Research (Winthrop P. Rockefeller Cancer Institute)

Postdoctoral Positions – Cancer and Infection (Boston Children’s Hospital)

Postdoctoral Research Scientist – Cancer Research (The Beatson Institute for Cancer Research)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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