Pulmonary Cell News 9.12 April 2, 2020 | |
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TOP STORYKMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer Pharmacological inhibition of glycolysis preferentially impeded tumorigenicity of human lung cancer cells bearing KMT2D-inactivating mutations. [Cancer Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the cytotoxic and inflammatory potential of CeO2 nanoparticles in a co-culture of A549 lung epithelial cells and differentiated THP-1 cells in both air-liquid interface and submerged conditions. Cellular dose was examined quantitatively using inductively coupled plasma mass spectrometry. [Nanomaterials] Full Article GDF-15 Prevents Lipopolysaccharide-Mediated Acute Lung Injury via Upregulating SIRT1 The authors found that growth differentiation factor-15 (GDF-15) was upregulated upon LPS stimulation in murine lungs and human alveolar epithelial cells. GDF-15 treatment prevented, whereas Gdf-15 silence aggravated LPS-induced inflammation, oxidative stress and apoptosis. [Biochem Biophys Res Commun] Abstract LUNG CANCERA Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers Researchers report that half of KRAS-mutant non-small cell lung cancers aberrantly expressed the homeobox protein HOXC10, largely due to unappreciated defects in PRC2, which conferred sensitivity to combined BET/MEK inhibitors in xenograft and PDX models. [Cancer Cell] Abstract | Graphical Abstract Microenvironmental Th9- and Th17- Lymphocytes Induce Metastatic Spreading in Lung Cancer The authors explored the impact of tumor-infiltrating-lymphocyte subpopulations on lung cancer biology by studying in vitro co-cultures, in vivo mouse models and human lung cancer tissue. [J Clin Invest] Abstract | Graphical Abstract UFC1 knockdown inhibited non-small cell lung cancer cell proliferation, migration and invasion while promoted cell cycle arrest and apoptosis. UFC1 overexpression led to the opposite effects. [Cell Death Dis] Full Article The in vitro PDT effects of Si-3a and Si-4a were investigated using the MTT cell viability assay against HCT-116, A549 and SH-SY5Y cell lines. [Dalton Trans] Abstract In culture, human alveolar adenocarcinoma basal epithelial cell line and immortalized human bronchial epithelial cell line internalized alginate-based nanoparticles through non-selective endocytosis. [Nanomaterials] Abstract | Download Full Article Pemetrexed Sensitizes Human Lung Cancer Cells to Cytotoxic Immune Cells Researchers examined the effects of pemetrexed on the sensitivity of human non-small-cell lung cancer cells to two different types of cytotoxic immune cells. [Cancer Sci] Abstract Cisplatin-resistant variants were established from three non-small cell lung cancer cell lines and two small cell lung cancer cell lines. [Cancer Chemother Pharmacol] Abstract AG-1031 treated A549 cells and tumors from AG-1031 treated animals showed a significant decrease in the levels of both positive coactivator 4 and VEGFC, a key mediator of angiogenesis in cancer. [PLoS One] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSThe Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future The authors discuss key aspects of lung repair and regeneration. They focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration. [Cell Stem Cell] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSVerona Pharma plc announced positive efficacy and safety data with a single dose of pressurized metered-dose inhaler formulation of ensifentrine in a Phase II clinical trial in patients with moderate to severe chronic obstructive pulmonary disease. [Verona Pharma plc] Press Release Keith Murphy, founder and Chief Executive Officer of Viscient Biosciences is calling for a pause in the merger attempt of Organovo Holdings, Inc, after Organovo failed to receive enough votes to consummate the merger. [Viscient Biosciences (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSCull, Release or Bring Them Home: Coronavirus Crisis Forces Hard Decisions for Labs with Animals As universities scale back operations and scientists observe stay-at-home orders, many are struggling to protect their research and the animals that power it. [Nature News] Editorial Tens of Thousands of Scientists Are Redeploying to Fight Coronavirus As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise. [Nature News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – SARS-CoV-2 Lung Infection (Markus Bosmann) Research Fellow – Respiratory Viruses (Queen’s University Belfast) PhD Student – Lung Cancer (University Hospital Cologne) Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University) Postdoctoral Position – Lung Organoids (Columbia University Medical Center) Postdoctoral Research Associate – Lung Injury (University of Illinois at Chicago) Research Associate – Cystic Fibrosis (Michigan State University) Research Associate – Lung Tumors (University of Cambridge) Research Associate and Lab Manager – In Vitro Cancer Models (Flanders Institute for Biotechnology) Postdoctoral Scholar – Cancer Metabolism (The Ohio State University) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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