Pulmonary Cell News 9.18 May 14, 2020 | |
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TOP STORYThe authors found that miR-1193-3p, miR-411-3p and miR-370-3p exhibited potent anti-fibrotic effects while miR-292-5p demonstrated pro-fibrotic effects in TGF-β1-stimulated lung fibroblasts. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists co-cultured a human lung equivalent from the commercially available bronchial MucilAir culture and human liver spheroids from HepaRG cells to assess the potential toxicity of inhaled substances under conditions that permit organ crosstalk. [Sci Rep] Full Article Soluble PM2.5 extract exposure in vitro decreased the viability and increased apoptosis of airway epithelial cells. [Sci Total Environ] Abstract | Graphical Abstract LUNG CANCERTo study the molecular/cellular mechanisms of increased resistance of non-small cell lung cancer (NSCLC) to ionizing radiation exposure, researchers compared A549 and H1299 cells, the two NSCLC cell lines. [Int J Mol Sci] Full Article Researchers found that micheliolide (MCL) exerted a tumor cell killing effect on non-small-cell lung cancer (NSCLC) cells in a dose-dependent manner, and MCL strongly sensitized p53-deficient NSCLC cells, but not the cells with wild-type p53 to irradiation. [Int J Mol Sci] Full Article Scientists identified the molecular biomarkers for HKB99 response in erlotinib-resistant HCC827ER cells and showed that HCC827ER cells displayed enhanced invasive pseudopodia structures as well as downregulated plasminogen activator inhibitor-2 . [Acta Pharmacol Sin] Abstract The authors showed that overexpression of MACC1-AS1 enhanced the stemness of non-small cell lung cancer cells, which was evident as the increased expression of cancer stem cell transcription factors, ALDH1 activity, and sphere-formation capacity, while knockdown of MACC1-AS1 decreased it. [Environ Toxicol] Abstract LINC00665 expression was upregulated in non-small-cell lung cancer (NSCLC) lung tissues and cells. Downregulated LINC00665 could arrest A549 and H1299 cell proliferation and invasion in vitro. [Biomed Pharmacother] Abstract | Graphical Abstract Scientists used K2-ethylenediaminetetraacetic acid plasma samples from non-small cell lung cancer patients and healthy donors, along with cell line DNA. [Mol Diagn Ther] Abstract 30.2-nm CLEO-nanoemulsion droplets significantly increased Cas-3 in A549 cells and decreased angiogenesis in chick embryo chorioallantoic membrane. [J Microencapsul] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSRecent Advances in the Anti-Lung Cancer Activity of Biosynthesized Gold Nanoparticles The authors focus on the advances in the anti-lung cancer activity of biosynthesized gold nanoparticles and its potential mechanisms. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSNovartis announced that FDA approved Tabrectaâ„¢, an oral MET inhibitor for adult patients with metastatic non-small cell lung cancer whose tumors have a mutation that leads to MET exon 14 skipping as detected by an FDA-approved test. [Novartis] Press Release Relief Therapeutics Holding AG announced that its US partner, NeuroRx Inc., has filed an investigational protocol with the FDA under the Coronavirus Treatment Acceleration Program to conduct a Phase II/III clinical trial assessing inhaled as a treatment for patients with non-acute lung injury caused by the SARS-CoV-2 virus. [Relief Therapeutics Holding AG] Press Release Bionical Emas and Jazz Pharmaceuticals have entered into an agreement to provide appropriate patients in the United States who have relapsed Small Cell Lung Cancer lurbinectedin via an Expanded Access Program. Lurbinectedin is an investigational drug under review by the FDA. [Bionical Emas] Press Release | |
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POLICY NEWSScientists Are Drowning in COVID-19 Papers. Can New Tools Keep Them Afloat? Backed by large technology firms and the White House, a loose-knit army of data scientists, software developers, and journal publishers are racing to create digital collections holding thousands of freely available papers that could be useful to ending the pandemic, and scrambling to build data-mining and search tools that can help researchers quickly find the information they seek. [ScienceInsider] Editorial House Democrats Include Research Dollars in Latest Pandemic Relief Package For US scientists, the good news is that the $3 trillion spending bill unveiled contains billions of dollars in new research funding. The bad news is that the bill is only a marker for negotiations with Senate Republicans and the White House on what more the federal government should do to help the country deal with the devastating economic and health effects of the pandemic. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Associate Professor – Cell Biology (Dana-Farber Cancer Institute) Postdoctoral Scientist – Lung Cancer Clinical Research (Instituto de Investigación Hospital) Principal Scientist – Respiratory Inflammation Research (Amgen Inc.) Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen) Branch Chief – Integrative Tumor Epidemiology (NIH National Cancer Institute) Laboratory Manager – Lung Diseases (Helmholtz Zentrum München) Postdoctoral Fellow – SARS-CoV-2 Lung Infection (Boston University) Research Fellow – Respiratory Viruses (Queen’s University Belfast) Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University) Research Associate – Cystic Fibrosis (Michigan State University) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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