| Vol. 9.23 – 18 June, 2020 |
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| Researchers tested an antisense oligonucleotide targeting the cystic fibrosis (CF) transmembrane conductance regulator c.3718-2477C>T mutation and showed that it effectively blocks aberrant splicing in primary bronchial epithelial cells from CF patients with the mutation. [Nucleic Acids Research] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays, and the miR-410-induced epithelial–mesenchymal transition and radioresistance were reversed by PI3K, Akt, and mTOR inhibitors or by restoring the expression of PTEN in non-small cell lung cancer cells. [Signal Transduction and Targeted Therapy] |
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| Researchers explored the role of Annexin A1 (ANXA1) in Influenza Type A viruses infection of A549 lung epithelial cells further in the context of RIG-I-dependent signaling using A549 and Crispr/Cas9 ANXA1 deleted cells. [Cell Death & Disease] |
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| Investigators showed that the profibrotic actions of TGF‐β were mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 reversed pulmonary fibrosis. [FASEB Journal] |
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| Scientists identified an organoid‐forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β‐catenin activity, which was enriched in club and alveolar epithelial type II cells. [Stem Cells] |
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| Phosphoproteomic analyses identified many protein kinase A (PKA) substrates and mechanisms of action. In particular, PKA activity was required for the propagation of small cell lung cancer stem cells in transplantation studies. [Cancer Cell] |
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| Investigators showed that our unique poly(2-oxazoline)–based nanomicellar formulation of Resiquimod, an imidazoquinoline Toll-like receptor 7/8 agonist, had a superior tumor inhibitory effect in a metastatic model of lung adenocarcinoma, relative to anti–PD-1 therapy or platinum-based chemotherapy. [Science Advances] |
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| Scientists demonstrated for the first time the efficacy of Docetaxel liposomes in combination with telmisartan in 3D cultures of H460 cells by using polysaccharide-based hydrogels and also in xenograft model of Docetaxel resistant H460 derived CD133+ lung tumors. [Toxicology and Applied Pharmacology] |
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| Scientists investigated whether MDL-800, an allosteric activator of sirtuin 6, exerted antiproliferation effect against non-small cell lung carcinoma cells in vitro and in vivo. [Acta Pharmacologica Sinica] |
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| Scientists discuss the role of nuclear FAK as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment. [Experimental and Molecular Medicine] |
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| Nuvaira announced that its Nuvaira® Lung Denervation System has been designated as a Breakthrough Device by the FDA. [Nuvaira] |
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| Creatv Microtech has pioneered a blood test to predict treatment response in patients with stage II-III NSCLC treated with chemoradiation therapy and consolidated immunotherapy. [Business Wire, Inc.] |
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| 2020-06-22 – 2020-06-24 Virtual |
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| Virginia Commonwealth University – Richmond, Virginia, United States |
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| NYU School of Medicine – New York, New York, United States |
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| Helmholtz Zentrum München – Neuherberg, Germany |
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| Max Planck Institute for Heart and Lung Research – Bad Nauheim, Germany |
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| Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| Yale University – New Haven, Connecticut, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Amgen Inc. – South San Francisco, California, United States |
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| NIH National Cancer Institute – Bethesda, Maryland, United States |
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| Michigan State University – East Lansing, Michigan, United States |
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