Pulmonary Cell News Volume 9.23 | Jun 18 2020

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    2020-06-18 | PULCN 9.23


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.23 – 18 June, 2020
    TOP STORY

    Antisense Oligonucleotide-Mediated Correction of CFTR Splicing Improves Chloride Secretion in Cystic Fibrosis Patient-Derived Bronchial Epithelial Cells

    Researchers tested an antisense oligonucleotide targeting the cystic fibrosis (CF) transmembrane conductance regulator c.3718-2477C>T mutation and showed that it effectively blocks aberrant splicing in primary bronchial epithelial cells from CF patients with the mutation.
    [Nucleic Acids Research]

    Full Article

    Scientific resources to support your organoids research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    miR-410 Induces Both Epithelial-Mesenchymal Transition and Radioresistance through Activation of the PI3K/mTOR Pathway in Non-Small Cell Lung Cancer

    Scientists demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays, and the miR-410-induced epithelial–mesenchymal transition and radioresistance were reversed by PI3K, Akt, and mTOR inhibitors or by restoring the expression of PTEN in non-small cell lung cancer cells.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Annexin-A1 Promotes RIG-I-Dependent Signaling and Apoptosis via Regulation of the IRF3–IFNAR–STAT1–IFIT1 Pathway in A549 Lung Epithelial Cells

    Researchers explored the role of Annexin A1 (ANXA1) in Influenza Type A viruses infection of A549 lung epithelial cells further in the context of RIG-I-dependent signaling using A549 and Crispr/Cas9 ANXA1 deleted cells.
    [Cell Death & Disease]

    Full Article

    SIRT7‐Mediated Modulation of Glutaminase 1 Regulates TGF‐β‐Induced Pulmonary Fibrosis

    Investigators showed that the profibrotic actions of TGF‐β were mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 reversed pulmonary fibrosis.
    [FASEB Journal]

    Full Article

    Wnt/β‐Catenin Signaling Is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema

    Scientists identified an organoid‐forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β‐catenin activity, which was enriched in club and alveolar epithelial type II cells.
    [Stem Cells]

    Full Article

    Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells

    Phosphoproteomic analyses identified many protein kinase A (PKA) substrates and mechanisms of action. In particular, PKA activity was required for the propagation of small cell lung cancer stem cells in transplantation studies.
    [Cancer Cell]

    AbstractGraphical Abstract

    High-Capacity Poly(2-oxazoline) Formulation of TLR 7/8 Agonist Extends Survival in a Chemo-Insensitive, Metastatic Model of Lung Adenocarcinoma

    Investigators showed that our unique poly(2-oxazoline)–based nanomicellar formulation of Resiquimod, an imidazoquinoline Toll-like receptor 7/8 agonist, had a superior tumor inhibitory effect in a metastatic model of lung adenocarcinoma, relative to anti–PD-1 therapy or platinum-based chemotherapy.
    [Science Advances]

    Full Article

    Targeting Lung Cancer Stem Cells Using Combination of Tel and Docetaxel Liposomes in 3D Cultures and Tumor Xenografts

    Scientists demonstrated for the first time the efficacy of Docetaxel liposomes in combination with telmisartan in 3D cultures of H460 cells by using polysaccharide-based hydrogels and also in xenograft model of Docetaxel resistant H460 derived CD133+ lung tumors.
    [Toxicology and Applied Pharmacology]

    AbstractGraphical Abstract

    MDL-800, An Allosteric Activator of SIRT6, Suppresses Proliferation and Enhances EGFR-TKIs Therapy in Non-Small Cell Lung Cancer

    Scientists investigated whether MDL-800, an allosteric activator of sirtuin 6, exerted antiproliferation effect against non-small cell lung carcinoma cells in vitro and in vivo.
    [Acta Pharmacologica Sinica]

    Abstract

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    REVIEWS

    Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

    Scientists discuss the role of nuclear FAK as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment.
    [Experimental and Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Nuvaira Announces FDA Breakthrough Designation for AIRFLOW-3 Pivotal Trial Device

    Nuvaira announced that its Nuvaira® Lung Denervation System has been designated as a Breakthrough Device by the FDA.
    [Nuvaira]

    Press Release

    Creatv Announces Ability to Predict Immunotherapy Treatment Response for Non-Small Cell Lung Cancer Using a Simple Blood Test

    Creatv Microtech has pioneered a blood test to predict treatment response in patients with stage II-III NSCLC treated with chemoradiation therapy and consolidated immunotherapy.
    [Business Wire, Inc.]

    Press Release

    FEATURED EVENT

    American Association for Cancer Research (AACR) Annual Meeting 2020 – Virtual Meeting II

    2020-06-22 – 2020-06-24
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Lung Cancer Biology

    Virginia Commonwealth University – Richmond, Virginia, United States

    Postdoctoral Positions – Single Molecule Biology

    NYU School of Medicine – New York, New York, United States

    Science Manager – Lung Diseases

    Helmholtz Zentrum München – Neuherberg, Germany

    Research Group Leader – Cardiopulmonary Institute

    Max Planck Institute for Heart and Lung Research – Bad Nauheim, Germany

    Postdoctoral Research Fellow – Viral and Bacterial Lung Infections

    Johns Hopkins University School of Medicine – Baltimore, Maryland, United States

    Postdoctoral Associate – Lung Cancer Research

    Yale University – New Haven, Connecticut, United States

    Associate Professor – Cell Biology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Principal Scientist – Respiratory Inflammation Research

    Amgen Inc. – South San Francisco, California, United States

    Branch Chief – Integrative Tumor Epidemiology

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Research Associate – Cystic Fibrosis

    Michigan State University – East Lansing, Michigan, United States

    > See All Jobs

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