Pulmonary Cell News Volume 9.28 | Jul 23 2020

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    Justin.choi
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    2020-07-23 | PULCN 9.28


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.28 – 23 July, 2020
    TOP STORY

    Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

    The authors profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma.
    [Cancer Cell]

    AbstractGraphical Abstract

    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung

    Researchers sought to decipher the transcriptome of freshly isolated epithelial cells from normal and idiopathic pulmonary fibrosis lung to discern disease-dependent changes within basal stem cells.
    [American Journal of Respiratory and Critical Care Medicine]

    Abstract

    3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

    Investigators employed mouse 3D cell culture models and imaging to study ex vivo the role of FGF ligands and the interplay of FGF signaling with epithelial growth factor and WNT signaling pathways in lung epithelial morphogenesis and differentiation.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Post-Transcriptional Air Pollution Oxidation to the Cholesterol Biosynthesis Pathway Promotes Pulmonary Stress Phenotypes

    Scientists developed a method for 8-oxo-7,8-dihydroguanine profiling using immunocapturing and RNA sequencing. They found 42 oxidized transcripts in bronchial epithelial BEAS-2B cells exposed to two air pollution mixtures that recreate urban atmospheres.
    [Communications Biology]

    Full Article

    Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection

    In the context of Pseudomonas aeruginosa infection, brushings from the airways of cystic fibrosis recipients demonstrated type 1 interferon gene suppression.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia

    Researchers used reconstituted human airway epithelia to isolate and then characterized the viral infection kinetics, tissue-level remodeling of the cellular ultrastructure, and transcriptional early immune signatures induced by SARS-CoV-2 in a physiologically relevant model.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    LUNG CANCER

    Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

    Scientists used single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma. They identified an epigenomic continuum representing loss of cellular identity and progression toward a metastatic state.
    [Cancer Cell]

    AbstractGraphical Abstract

    TRIB3-EGFR Interaction Promotes Lung Cancer Progression and Defines a Therapeutic Target

    Researchers report that the elevated tribbles pseudokinase 3 (TRIB3) was positively associated with epidermal growth factor receptor (EGFR) stability and non-small cell lung cancer progression.
    [Nature Communications]

    Full Article

    Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma

    Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
    [Cancer Research]

    Abstract

    A Novel TRPM7/O-GlcNAc Axis Mediates Tumor Cell Motility and Metastasis by Stabilising c-Myc and Caveolin-1 in Lung Carcinoma

    Inhibition of TRPM7 suppressed cell motility in various non-small cell lung cancer cell lines and patient-derived primary cells and attenuated experimental lung metastases.
    [British Journal of Cancer]

    Full Article

    Discovery of New Fluorescent Thiazole–Pyrazoline Derivatives as Autophagy Inducers by Inhibiting mTOR Activity in A549 Human Lung Cancer Cells

    A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by 1H NMR, 13C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer A549 cells in a dose- and time-dependent manner in vitro and inhibit tumor growth in vivo.
    [Cell Death & Disease]

    Full Article

    NRF2-GPX4/SOD2 Axis Imparts Resistance to EGFR-Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cells

    The authors investigated the role of NRF2 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). They showed that NRF2 protein levels were markedly increased in a panel of EGFR-TKI-resistant non-small cell lung cancer cell lines due to slow degradation of NRF2 protein.
    [Acta Pharmacologica Sinica]

    Abstract

    Virtual Conference Exhibition: Organoids
    REVIEWS

    Cell–Cell Interaction Mechanisms in Acute Lung Injury

    Scientists provide an overview of current advancements in understanding the role of cell–cell interaction in the development of acute lung injury (ALI) and depict molecular mechanisms by which cell–cell interactions regulate lung inflammation, focusing on inter-cellular activities and signaling pathways that point to possible therapeutic opportunities for ALI/acute respiratory distress syndrome.
    [Shock]

    Abstract

    INDUSTRY AND POLICY NEWS

    Lantern Pharma Establishes Manufacturing Network in Preparation for Its Phase II Clinical Trial for the Treatment of Non-Small Cell Lung Cancer and a Phase I Clinical Trial for Solid Tumors and Glioblastoma

    Lantern Pharma announced entering into agreements with leading contract manufacturing companies for process development and manufacturing for two of Lantern’s oncology drug candidates, LP-300 and LP-184.
    [Lantern Pharma Inc.]

    Press Release

    Sanford Burnham Prebys Receives CIRM Award for COVID-19 Research

    Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine to advance promising drug candidates for COVID-19.
    [Sanford Burnham Prebys Medical Discovery Institute]

    Press Release

    Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

    For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
    [ScienceInsider]

    Editorial

    FEATURED EVENT

    2020 Cancer Cachexia Conference

    September 10 – September 11
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Computational Medicine of the Lungs

    Institute for Computational Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Researcher – Inhalation and Developmental Toxicology

    Louisiana State University – Baton Rouge, Louisiana, United States

    Postdoctoral Research Fellow – Biology of Small Cell Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Fellow – Lung Cancer Biology

    Virginia Commonwealth University – Richmond, Virginia, United States

    > See All Jobs

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