Pulmonary Cell News Volume 9.37 | Sep 24 2020

May 12, 2022

2020-24-09 | PULCN 9.37

Pulmonary Cell News by STEMCELL Technologies

Vol. 9.37 – 24 September, 2020

TOP STORY

Cholesterol
25‐Hydroxylase Inhibits SARS‐CoV‐2 and Coronaviruses by Depleting Membrane Cholesterol

Researchers report that one of the interferon‐stimulated genes, cholesterol 25‐hydroxylase, was induced by SARS‐CoV‐2 infection in vitro and in COVID‐19 patients.
[EMBO Journal]

Abstract

Watch 'collaborating to accelerate COVID-19 research'

PUBLICATIONSRanked by the impact factor of the journal

A
Novel Lung Alveolar Cell Model for Exploring Volatile Biomarkers of Particle-Induced Lung Injury

Scientists exposed the human alveolar A549 cell line to 0, 200, and 500 μg/mL quartz particles for 24 hours and used gas chromatography–mass spectrometry to measure the volatile metabolites in the headspace air of cells.
[Scientific Reports]

Full Article

LUNG CANCER

MBIP
(MAP3K12 Binding Inhibitory Protein) Drives NSCLC Metastasis by JNK-Dependent Activation of MMPs

Researchers characterized the contribution of one of the identified genes, MBIP, towards driving tumor invasion and metastasis. They demonstrated that expression of MBIP significantly enhanced the cellular proliferation, migration and invasion of NSCLC cells in vitro and metastasis in vivo.
[Oncogene]

Abstract

CB11,
a Novel Purine-Based PPARɣ Ligand, Overcomes Radio-Resistance by Regulating ATM Signaling and EMT in Human Non-Small-Cell Lung Cancer Cells

CB11 caused cell death via reactive oxygen species-mediated ATM-p53-GADD45α signaling in human non-small-cell lung cancer cells, and diphenyleneiodonium, an NADPH oxidase inhibitor, decreased cell death by inhibiting CB11-mediated ATM signaling.
[British Journal of Cancer]

Abstract

Silencing
of lncRNA LINC00857 Enhances BIRC5-Dependent Radio-Sensitivity of Lung Adenocarcinoma Cells by Recruiting NFκB1

The authors identified a long noncoding RNA LINC00857 that might regulate radio-sensitivity of lung adenocarcinoma cells.
[Molecular Therapy-Nucleic Acids]

Abstract Graphical Abstract

miR-196b-5p-Mediated
Downregulation of FAS Promotes NSCLC Progression by Activating IL6-STAT3 Signaling

Investigators found that miR-196b-5p promoted lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS.
[Cell Death & Disease]

Full Article

Ruthenium (II) Complex cis-[Ru^II(ŋ²-O₂CC₇H₇O₂)(dppm)₂]PF₆-hmxbato Induces ROS-Mediated Apoptosis in Lung Tumor Cells Producing Selective Cytotoxicity

Scientists analyzed the anticancer potential of hmxbato against lung tumor cells, as well as the partial death mechanisms involved.
[Scientific Reports]

Full Article

Nitidine
Chloride Possesses Anticancer Property in Lung Cancer Cells through Activating Hippo Signaling Pathway

The authors investigated the anti-tumor functions and the feasible molecular basis of nitidine chloride in NSCLC cells.
[Cell Death Discovery]

Full Article

miR-34c-3p
Targets CDK1 a Synthetic Lethality Partner of KRAS in Non-Small Cell Lung Cancer

In vitro assays on immortalized and patient-derived primary non-small cell lung cancer cells revealed that miR-34c-3p overexpression increased apoptosis and lowered proliferation rate in KRAS^mut cells.
[Cancer Gene Therapy]

Full Article

MicroRNA-130b-3p
Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis

A tumor xenograft mouse model was used to determine role of extracellular vesicles-microRNA-130b-3p and its target FOXO3 in lung cancer progression in vivo.
[Molecular Therapy-Oncolytics]

Abstract Full Article
Graphical Abstract

REVIEWS

Expression
and Role of p16 and GLUT1 in Malignant Diseases and Lung Cancer: A Review

Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth.
[Thoracic Cancer]

Full Article

INDUSTRY AND POLICY NEWS

Janssen
Presents Findings from Global, Multi-Center Trial Examining Amivantamab in Combination with Lazertinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer

The Janssen Pharmaceutical Companies of Johnson & Johnson announced interim results from the CHRYSALIS study, evaluating amivantamab, a fully human bispecific antibody that targets epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor mutations, in combination with the third-generation EGFR tyrosine kinase inhibitor lazertinib in patients with non-small cell lung cancer with EGFR exon 19 deletions or L858R mutations.
[Janssen Global Services, LLC]

Press Release

Bristol Myers Squibb Receives Positive CHMP Opinion Recommending Approval of Opdivo (Nivolumab) plus Yervoy (Ipilimumab) Combined with Two Cycles of Chemotherapy as First-Line Treatment of Metastatic Non-Small Cell Lung Cancer

Bristol Myers Squibb announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended approval of Opdivo^® plus Yervoy^® with two cycles of platinum-based chemotherapy for the first-line treatment of metastatic non-small cell lung cancer in adults whose tumors have no sensitizing EGFR mutation or ALK translocation.
[Bristol Myers Squibb]

Press Release

FEATURED EVENT

Cholesterol
25‐Hydroxylase Inhibits SARS‐CoV‐2 and Coronaviruses by Depleting Membrane Cholesterol

A
Novel Lung Alveolar Cell Model for Exploring Volatile Biomarkers of Particle-Induced Lung Injury

MBIP
(MAP3K12 Binding Inhibitory Protein) Drives NSCLC Metastasis by JNK-Dependent Activation of MMPs

CB11,
a Novel Purine-Based PPARɣ Ligand, Overcomes Radio-Resistance by Regulating ATM Signaling and EMT in Human Non-Small-Cell Lung Cancer Cells

Silencing
of lncRNA LINC00857 Enhances BIRC5-Dependent Radio-Sensitivity of Lung Adenocarcinoma Cells by Recruiting NFκB1

miR-196b-5p-Mediated
Downregulation of FAS Promotes NSCLC Progression by Activating IL6-STAT3 Signaling

Ruthenium (II) Complex cis-[Ru^II(ŋ²-O₂CC₇H₇O₂)(dppm)₂]PF₆-hmxbato Induces ROS-Mediated Apoptosis in Lung Tumor Cells Producing Selective Cytotoxicity

Nitidine
Chloride Possesses Anticancer Property in Lung Cancer Cells through Activating Hippo Signaling Pathway

miR-34c-3p
Targets CDK1 a Synthetic Lethality Partner of KRAS in Non-Small Cell Lung Cancer

MicroRNA-130b-3p
Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis

Expression
and Role of p16 and GLUT1 in Malignant Diseases and Lung Cancer: A Review

Janssen
Presents Findings from Global, Multi-Center Trial Examining Amivantamab in Combination with Lazertinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer

Bristol Myers Squibb Receives Positive CHMP Opinion Recommending Approval of Opdivo (Nivolumab) plus Yervoy (Ipilimumab) Combined with Two Cycles of Chemotherapy as First-Line Treatment of Metastatic Non-Small Cell Lung Cancer

Asthma: New Discoveries and Therapies in the Age of COVID

> See All Events

Postdoctoral
Research Associate – Acute Lung Injury

Postdoctoral
Fellow – Parenchymal/Vascular Lung Disease

Postdoctoral
Positions – Signal Transduction

Postdoctoral Position – Lung Regeneration and Pollution

Margaret
Turner Warwick Chair of Thoracic Medicine – Fibrosing Lung Disease

> See All Jobs