Pulmonary Cell News Volume 9.48 | Dec 10 2020

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    2020-10-12 | PULCN 9.48


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 9.48 – 10 December, 2020
    TOP STORY

    Enteroviral 3C Protease Activates the Human NLRP1 Inflammasome in Airway Epithelia

    Infection of primary human airway epithelial cells by live human human rhinovirus triggered NACHT, LRR, and PYD domains-containing protein 1 (NLRP1)-dependent inflammasome activation and interleukin-18 secretion.
    [Science]

    Abstract

    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    Obesity-Induced Vitamin D Deficiency Contributes to Lung Fibrosis and Airway Hyperresponsiveness

    In vivo effect of vitamin D (VitD) supplementation were analyzed using high fat diet induced obese mice and TGF-β1 triple transgenic mice. Effects of VitD supplementation were also evaluated in both BEAS-2B and primary lung cells from the transgenic mice.
    [American Journal of Respiratory Cell and Molecular Biology]

    Abstract

    Geomagnetic Shielding Enhances Radiation Resistance by Promoting DNA Repair Process in Human Bronchial Epithelial Cells

    Immortalized human bronchial epithelial cells were exposed to X-rays under either a geomagnetic field or hypomagnetic field (HMF) culture condition. A significant increase of the cell survival rate in HMF after radiation was observed by colony formation analysis.
    [International Journal of Molecular Sciences]

    Full Article

    Nitidine Chloride Suppresses NEDD4 Expression in Lung Cancer Cells

    The authors aimed to determine the biological effect of nitidine chloride (NC) and the underlying molecular insights in lung cancer cells. The antineoplastic function of NC was assessed by MTT assays, Annexin V-FITC/PI apoptosis assay, wound healing analysis, and Transwell chamber migration and invasion assay in lung cancer cells.
    [Aging]

    Full Article

    G9a Promotes Invasion and Metastasis of Non-Small Cell Lung Cancer through Enhancing Focal Adhesion Kinase Activation via NF-κB Signaling Pathway

    Researchers investigated the effect and underlying mechanisms of euchromatic histone methyltransferase 2 (G9a), and therapeutic implications of targeting G9a in the invasion and metastasis of non-small cell lung cancer.
    [Molecular Cancer Research]

    Abstract

    In Vitro and In Vivo Inhibitory Effect of Citrus junos Tanaka Peel Extract against Oxidative Stress-Induced Apoptotic Death of Lung Cells

    Investigators demonstrated the inhibitory effect of Citrus junos Tanaka peel extract against the oxidative stress-induced apoptosis of lung cells under a highly oxidative environment.
    [Antioxidants]

    Full Article

    MicroRNA-let-7e in Serum-Derived Exosomes Inhibits the Metastasis of Non-Small-Cell Lung Cancer in a SUV39H2/LSD1/CDH1-Dependent Manner

    Researchers evaluated the clinical significance of serum-derived exosomal miR-let-7e as a biomarker in the metastasis of non-small-cell lung cancer.
    [Cancer Gene Therapy]

    Abstract

    Downregulation of miR-506-3p Facilitates EGFR-TKI Resistance through Induction of Sonic Hedgehog Signaling in Non-Small-Cell Lung Cancer Cell Lines

    Scientists report that miR-506-3p expression was markedly reduced in erlotinib-resistant (ER) cells. They identified Sonic Hedgehog as a novel target of miR-506-3p, aberrantly activated in ER cells.
    [International Journal of Molecular Sciences]

    Full Article

    EZH2 Inhibitors Reverse Resistance to Gefitinib in Primary EGFR Wild-Type Lung Cancer Cells

    The authors investigated whether the enhancer of zeste homolog 2 (EZH2) inhibitors, GSK343 and DZNep when combined with gefitinib can reverse epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistance in EGFR wild-type non-small cell lung cancer cells.
    [BMC Cancer]

    Full Article


    Learn about optimization of in vitro lung models in this webinar by Dr. Rachael Rayner
    REVIEWS

    Modeling Multi-Organ Infection by SARS-CoV-2 Using Stem Cell Technology

    Scientists describe how the contribution of stem-cell-derived culture systems have helped the understanding of SARS-CoV-2 pathogenesis.
    [Cell Stem Cell]

    Full Article

    INDUSTRY AND POLICY NEWS

    Janssen Submits Application to US FDA Seeking Approval of Amivantamab for the Treatment of Patients with Metastatic Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations

    The Janssen Pharmaceutical Companies of Johnson & Johnson announced the submission of a Biologics License Application to the FDA seeking approval of amivantamab for the treatment of patients with metastatic non-small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy.
    [The Janssen Pharmaceutical Companies of Johnson & Johnson]

    Press Release

    FEATURED EVENT

    Eradicate Cancer

    January 15 – 16, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Tissue Engineering of the Lung

    Columbia University – New York, New York, United States

    Research Assistant – Asthma Research

    Philipps-Universität Marburg – Marburg, Germany

    Postdoctoral Fellow Position – Host-Pathogen Interactions

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Fellowship – Pro-Metastatic Tumor Microenvironment

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Faculty Position – Oncology & Lung Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    > See All Jobs

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