Regulation of Apoptosis and Autophagy by Albendazole in Human Colon Adenocarcinoma Cells
Researchers found that Albendazole induced the subG1 arrest during cell cycle progression, increased the late apoptotic cells, shifted of peak TUNEL-labeled cells peak, and induced apoptosis.
[Nature Communications] Investigators reported that miR-21 enhanced glucose uptake and subsequently promoted insulin secretion by up-regulating Glut2 expression in a miR-21-Pdcd4-AP-1 dependent pathway.
[Immunity] Single-cell RNA sequencing revealed the heterogeneity of pancreatic stellate cell (PSCs) and identified very-low-density lipoprotein receptor+ PSCs that were characterized by a higher lipid metabolism.
[Cancer Letters] The authors reported that aortic carboxypeptidase–like protein (ACLP) was mainly expressed in cancer-associated fibroblasts (CAFs) but not in cancer cells and highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues.