LGR4 Cooperates with PrPc to Endow the Stemness of Colorectal Cancer Stem Cells Contributing to Tumorigenesis and Liver Metastasis

Researchers reported that a leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) cooperated with CD44 and PrPc; the latter contributed significantly to metastatic capacity and defined the stemness characteristics of colorectal CSCs.