TFEB and TFE3 Depletion Increases Cancer Stem Cell Characteristics and EMT in Triple-Negative Breast Cancer

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Scientists showed that knockout of TFEB and combined knockout of TFEB and TFE3 resulted in an increase in stem cell character and epithelial-mesenchymal transition, which could correlate to increased tumor metastasis and poorer prognosis.
[FASEB Journal]
Abstract