Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes That Drive Cellular Aging
Investigators found that the epigenetic de-repression unlocked the expression of pregnancy-specific beta-1 glycoprotein genes that exacerbate human mesenchymal progenitor cells aging and serve as potential aging biomarkers.
[British Journal of Pharmacology] In vivo, investigators studied the role of Caspase-11 in several angiogenesis mouse models using Caspase-11 wild-type and knockout mice. In vitro, scientists detected the effects of Caspase-4 on endothelial functions and Notch signaling by depleting or overexpressing Caspase-4 in HUVECs.
[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified the reversible SUMOylation of FGF receptor 1 (FGFR1) as an intrinsic fine-tuned mechanism in coordinating endothelial angiogenic signaling during neovascularization.