CRISPR/Cas9 Screens Reveal That Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway

HK2 enhanced the accumulation of acetyl-CoA and epigenetically activated the transcription of acyl-CoA synthetase long-chain family member 4, leading to an increase in fatty acid β-oxidation activity.