Characteristics of the Cancer Stem Cell Niche and Therapeutic Strategies
The authors summarize and discuss the latest findings regarding CSC niche morphology, physical terrain, main signaling pathways and interactions within them.
[Oncogenesis] By using both mouse and human TNBC cell lines, investigators found that diltiazem decreased colony formation and cell migration in breast cancer cells.
[Nature Cell Biology] Researchers discovered that a C2H2 zinc finger protein, ZNF827, is strongly induced during various contexts of epithelial-to-mesenchymal transition (EMT), including in brain development and breast cancer metastasis.
[Molecular Therapy Oncolytics] In an ex vivoassay, the size of freshly isolated human breast cancer tissues, including ER-positive & negative as well as HER2-positive & negative, was reduced by YS49-treated mesenchymal stem cell (MSC) derived conditioned medium.