CD49b Identifies Functionally and Epigenetically Distinct Subsets of Lineage-Biased Hematopoietic Stem Cells

The authors demonstrated that CD49b subdivides the most primitive hematopoietic stem cell (HSC) compartment into functionally distinct subtypes: CD49b− HSCs are highly enriched for myeloid-biased and the most durable cells, while CD49b+ HSCs are enriched for multipotent cells with lymphoid bias and reduced self-renewal ability.