Airway Prevotella Promote TLR2-Dependent Neutrophil Activation and Rapid Clearance of Streptococcus pneumoniae From the Lung
Scientists showed that Prevotella melaninogenica enhanced protection against Streptococcus pneumoniae, resulting in rapid pathogen clearance from the lung and improved survival in a mouse lung co-infection model.
[British Journal of Pharmacology] In vivo, investigators studied the role of Caspase-11 in several angiogenesis mouse models using Caspase-11 wild-type and knockout mice. In vitro, scientists detected the effects of Caspase-4 on endothelial functions and Notch signaling by depleting or overexpressing Caspase-4 in HUVECs.
[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified the reversible SUMOylation of FGF receptor 1 (FGFR1) as an intrinsic fine-tuned mechanism in coordinating endothelial angiogenic signaling during neovascularization.