Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis.

The authors found that activation of hepatocyte p53 created a microenvironment prone to tumor formation from hepatic progenitor cells and that optimization of p53 activity in hepatocytes was important to prevent chronic liver disease patients from hepatocarcinogenesis.
[Cancer Research]

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News