Active Force Generation Contributes to the Complexity of Spontaneous Activity and to the Response to Stretch of Murine Cardiomyocyte Cultures

Using stretchable microelectrode arrays, we assessed the effects of the myosin inhibitor blebbistatin and the nonselective stretch-activated channel blocker streptomycin on beating variability and on the response of neonatal or fetal murine ventricular cell cultures against deformation.