SARS-CoV-2 Infects an In Vitro Model of the Human Developing Pancreas through Endocytosis

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Using human fetal pancreas samples and 3D differentiation of human pluripotent cells into pancreatic endocrine cells, the authors determined that SARS-CoV-2 receptors ACE2, TMPRSS2, and NRP1 were expressed in precursors of insulin-producing pancreatic β-cells, rendering them permissive to SARS-CoV-2 infection.
[iScience]
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