Stoichiometric Post Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds

To create plain hydrogel microparticles (HMPs) that could later be converted to contain different types of bioactivities, scientists utilized the inverse electron-demand Deiels-Alder reaction between tetrazine and norbornene, which allowed them to post modify plain HMPs stoichiometrically.