Single-Cell Transcriptomics and Surface Epitope Detection in Human Brain Epileptic Lesions Identifies Pro-inflammatory Signaling

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Investigators used single-cell cellular indexing of transcriptomes and epitopes by sequencing to reveal the immunotranscriptome of surgically resected epileptic lesion tissues. Their approach uncovered a pro-inflammatory microenvironment, including extensive activation of microglia and infiltration of other pro-inflammatory immune cells.
[Nature Neuroscience]
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