Human Organ Rejuvenation by VEGF-A: Lessons from the Skin

While intradermally injected vascular endothelial growth factor (VEGF)-loaded nanoparticles sufficed to induce a molecular rejuvenation signature in aged human skin on old mice, VEGF-A treatment improved key aging parameters also in isolated, organ-cultured aged human skin, i.e., in the absence of functional skin vasculature, neural, or murine host inputs.