Mice with Trp53 and Rb1 Deficiency in Chondrocytes Spontaneously Develop Chondrosarcoma via Overactivation of YAP Signaling

Researchers generated a new transgenic chondrosarcoma model by double conditional deletions of Trp53 and Rb1 in chondrocyte lineage which spontaneously caused spinal chondrosarcoma and lung metastasis.