ACLP Promotes Activation of Cancer-Associated Fibroblasts and Tumor Metastasis via ACLP-PPARγ-ACLP Feedback Loop in Pancreatic Cancer

The authors reported that aortic carboxypeptidase–like protein (ACLP) was mainly expressed in cancer-associated fibroblasts (CAFs) but not in cancer cells and highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues.