Aberrant APOBEC3C Expression Induces Characteristic Genomic Instability in Pancreatic Ductal Adenocarcinoma

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3C)-overexpressing cell lines were generated to substantiate the effects of APOBEC3C on the PDAC genome, including alterations in single-nucleotide variant classes and the formation of kataegis regions.